PMID: 8938128Nov 1, 1996Paper

A role of intracellular Na+ in the regulation of synaptic transmission and turnover of the vesicular pool in cultured hippocampal cells

Neuron
A Bouron, H Reuter

Abstract

Propagation of action potentials in axons and dendrites increases intracellular Na+ ([Na+]i) and Ca2+ concentrations ([Ca2+]i). While the importance of [Ca2+]i in synaptic transmission is well established, a possible functional role of [Na+]i is unclear. In cultured hippocampal cells, [Na+]i was increased by veratridine. We have then measured spontaneous excitatory postsynaptic currents (sEPSCs) and, by means of fluorescent dyes, changes in [Na+]i, in [Ca2+]i, and in the turnover of the vesicular pool of individual boutons. An elevation of [Na+]i and a concomitant rise in [Ca2+]i, led to a large increase in sEPSC frequency and in the turnover of the presynaptic vesicular pool. Extracellular Ca2+ was essential for these effects of elevated [Na+]i on synaptic transmission. They probably occur via Na+/Ca2+ exchange.

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Citations

Jan 18, 2005·Pflügers Archiv : European journal of physiology·Héctor G Marrero, José R Lemos
Jun 5, 2002·Journal of Neuroscience Methods·Andre R MassensiniMarco A Romano-Silva
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Feb 9, 2002·British Journal of Pharmacology·Hisashi YamanakaNorio Akaike
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Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·A Bouron, H Reuter
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Aug 5, 1999·The Journal of Physiology·K JensenJ D Lambert
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Jun 24, 2003·Neuron·Daejong JeonHee-Sup Shin
Apr 25, 2006·Cell·Lutz G W HilgenbergMartin A Smith
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrea LörinczGábor Tamás
Dec 7, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·C R Rose
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Jun 29, 2018·Acta Pharmacologica Sinica·Xiao-Yu ZhangYe-Hua Gan
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Oct 14, 2021·Cell Reports·Sreerag Othayoth Vasu, Hanoch Kaphzan

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