A role of neuropeptide CART in hyperphagia and weight gain induced by olanzapine treatment in rats

Brain Research
K T NakhateDadasaheb M Kokare

Abstract

Although olanzapine is highly efficacious and most widely used second generation antipsychotic drug, the success of treatment has been hampered by its propensity to induce weight gain. While the underlying neuronal mechanisms are unclear, their elucidation may help to target alternative pathways regulating energy balance. The present study was undertaken to define the role of cocaine- and amphetamine-regulated transcript (CART), a well-known anorexic peptide, in olanzapine-induced hyperphagia and body weight gain in female rats. Olanzapine was administered daily by intraperitoneal route, alone or in combination with CART (intracerebroventricular) for a period of two weeks. Immediately after drug administrations, preweighed food was offered to the animals at the commencement of the dark phase. The food intake and body weight were measured daily just prior to next injection. Furthermore, the brains of olanzapine-treated rats were processed for the immunohistochemical analysis of CART-containing elements in the hypothalamus. Treatment with olanzapine (0.5 mg/kg) for the duration of 14 days produced a significant increase in food intake and body weight as compared to control. However, concomitant administration of CART (0.5 µg) att...Continue Reading

Citations

Oct 12, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Polina A VishnyakovaPetr M Masliukov
Jul 24, 2021·Translational Psychiatry·Rizaldy C ZapataOlivia Osborn

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