PMID: 11924732Apr 2, 2002Paper

A role of oxidative stress-generated eicosanoid in the progression of arteriosclerosis in type 2 diabetes mellitus model rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Kaori ShinomiyaShoichi Senda

Abstract

Diabetes mellitus (DM) is a well-established risk factor of cardiovascular diseases. We investigated the mechanism of the progression of arteriosclerosis in DM, focusing on the role of oxidative stress and insulin resistance in vivo. Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an experimental model of type 2 DM, were assigned to 3 groups, based on supplementation with vitamin E (VE) or troglitazone (TR), a VE-derived agent which improves insulin-resistance. At 36 weeks, plasma and aortic tissue 8-iso-PGF2alpha contents, a vascular proliferating eicosanoid produced in vivo by oxidative stress, were measured by EIA. TGF-beta1 and TGF-beta1 receptor II were immunohistochemically analyzed. Histopathologically, medial area and the nuclear number of smooth muscle cells of the aorta were measured. The tissue 8-iso-PGF2alpha content (pg/g tissue) was significantly decreased by either VE or TR in the aorta (untreated-OLETF, 15,332+/-3,254 vs. TR-treated-OLETF, 7,092+/-1,992 or VE-treated-OLETF, 5,394+/-836, both p<0.01), but that in plasma decreased by only VE. VE and TR improved the increased the level of the actual medial area and the number of smooth muscle cells. The expression of TGF-beta1 was reduced, but TGF-beta1 recept...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
Apr 1, 1983·The Journal of Clinical Investigation·G L KingL I Rand
Jan 1, 1995·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A Pfeiffer, H Schatz
Jan 1, 1994·Annual Review of Medicine·G M Fick, P A Gabow
Jun 1, 1993·The American Journal of Physiology·M FukunagaK F Badr
Mar 1, 1996·Diabetes Care·D GiuglianoG Paolisso
Jul 1, 1996·The American Journal of Physiology·R NatarajanJ Nadler
Oct 15, 1996·The Journal of Clinical Investigation·R E LawW A Hsueh
Jul 1, 1996·Circulation·M ReillyG A FitzGerald
Apr 1, 1997·Biochimica Et Biophysica Acta·L J Roberts, J D Morrow
Sep 16, 1999·Hypertension Research : Official Journal of the Japanese Society of Hypertension·M XoriuchiY Minokoshi
Mar 10, 2000·Cytokine & Growth Factor Reviews·T A McCaffrey
Apr 13, 2000·Journal of Internal Medicine·P Libby
Apr 19, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·N JokiK Kurokawa
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Dec 29, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·S KatayamaR Kikkawa
Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·M KyawT Tamaki

❮ Previous
Next ❯

Citations

May 9, 2007·Journal of Nutritional Science and Vitaminology·Takafumi MizushigeKiyoshi Ebihara
Apr 12, 2012·Cellular and Molecular Life Sciences : CMLS·Scott GleimJohn Hwa
Feb 21, 2007·Expert Opinion on Biological Therapy·Elena Gagliardini, Ariela Benigni
May 8, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A NishibeT Hata
Sep 11, 2007·Molecular Aspects of Medicine·Adelina Munteanu, Jean-Marc Zingg
Jul 13, 2007·Molecular Aspects of Medicine·Luis VillacortaJean-Marc Zingg
Mar 9, 2005·Annals of the New York Academy of Sciences·Joshua A Scott, George L King
Dec 14, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mojgan AfshariMohammad Abdollahi
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki DohiRyuzo Ueda
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuichiro WatariRyoji Ozono
Jul 17, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobuhisa HirotaTakao Saruta
Aug 18, 2004·Journal of the American College of Cardiology·Yang YuMasakazu Kohno
May 31, 2003·Journal of Cardiovascular Pharmacology·Tetsuya HayashiYasushi Kitaura
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Tatsuya KurokiGeorge L King

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.