A role of the bile salt receptor FXR in atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology
Jurre HagemanFolkert Kuipers

Abstract

This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism. At the molecular level, bile salts regulate lipid and energy homeostasis mainly via the bile salt receptors FXR and TGR5. Activation of FXR has been shown to improve plasma lipid profiles, whereas Fxr(-/-) mice have increased plasma triglyceride and very-low-density lipoprotein levels. Nevertheless, high-density lipoprotein cholesterol levels are increased in these mice, suggesting that FXR has both anti- and proatherosclerotic properties. Interestingly, there is increasing evidence for a role of FXR in "nonclassical" bile salt target tissues, eg, vasculature and macrophages. In these tissues, FXR has been shown to influence vascular tension and regulate the unloading of cholesterol from foam cells, respectively. Recent publications have provided insight into the antiinflammatory properties of FXR in atherosclerosis. Bile salt signaling via TGR5 might regulate energy homeostasis, which could serve as an attractive target to increase energy expenditure and weight loss. Interventions aiming to increase cholestero...Continue Reading

References

Aug 1, 1987·The American Journal of Medicine·J R Crouse
Jan 1, 1983·Annual Review of Nutrition·S M Grundy
May 21, 1999·Science·M MakishimaB Shan
May 21, 1999·Science·D J ParksJ M Lehmann
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·J L StaudingerS A Kliewer
Jun 28, 2001·Physiological Reviews·P M Yen
May 4, 2002·Science·Nancy L UrizarDavid D Moore
May 23, 2002·Science·Makoto MakishimaDavid J Mangelsdorf
Jun 14, 2002·Developmental Cell·Li WangDavid D Moore
Aug 1, 2002·The Journal of Biological Chemistry·Mayuko NakaharaRyuichiro Sato
Nov 8, 2002·The Journal of Biological Chemistry·Gilles LambertChristopher J Sinal
Jan 14, 2003·The Journal of Biological Chemistry·Yuji KawamataMasahiko Fujino
Jun 18, 2003·Journal of Lipid Research·B Ganesh BhatBradley T Keller
Aug 2, 2003·Gastroenterology·Thierry ClaudelBart Staels
Oct 1, 1958·The Biochemical Journal·H S WIGGINS, I D WOOTTON
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·David Bishop-BaileyTimothy D Warner
Mar 30, 2004·Diabetes·Daniel Duran-SandovalBart Staels
May 18, 2004·The Journal of Clinical Investigation·Mitsuhiro WatanabeJohan Auwerx
Nov 24, 2004·Nature Medicine·Antonio MoschettaDavid J Mangelsdorf
Dec 9, 2004·Current Opinion in Nephrology and Hypertension·Robert M Carey
Dec 17, 2004·Molecular Pharmacology·Thomas P BurrisKeith R Stayrook
Feb 22, 2005·Biochemical and Biophysical Research Communications·Susumu KatsumaGozoh Tsujimoto
May 19, 2005·The Journal of Biological Chemistry·Daniel Duran-SandovalBart Staels
Jun 11, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Vladimir R BabaevMacRae F Linton
Aug 3, 2005·The Journal of Clinical Investigation·Shinji ItoYo-Ichi Nabeshima
Sep 15, 2005·Atherosclerosis·Gianna FerrettiGiovanna Curatola

❮ Previous
Next ❯

Citations

Feb 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natarajan BalasubramaniyanFrederick J Suchy
Oct 13, 2011·Journal of Lipids·Tiangang Li, John Y L Chiang
Jun 21, 2011·Journal of Lipid Research·Yipeng SuiChangcheng Zhou
Jan 28, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan ZhangYoufei Guan
Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peggy P Ho, Lawrence Steinman
Nov 2, 2013·European Journal of Preventive Cardiology·Janine WirthCornelia Weikert
Feb 27, 2017·European Journal of Medicinal Chemistry·Guoning ZhangWeishuo Fang
Jan 18, 2014·Journal of Hepatology·Hanno Ehlken, Christoph Schramm
Feb 22, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Andrei VoiosuSøren Møller
Jan 16, 2018·Alimentary Pharmacology & Therapeutics·B HameedUNKNOWN NASH CRN
Mar 7, 2014·Molecular Endocrinology·Nidhi SinghSabyasachi Sanyal
Aug 25, 2011·American Journal of Physiology. Endocrinology and Metabolism·Tsuyoshi GotoTeruo Kawada
Aug 1, 2013·Physiological Reviews·Paul N Hopkins
Jul 31, 2014·Pharmacological Reviews·Tiangang Li, John Y L Chiang
Nov 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F Patrick Ross
Sep 26, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Paul M RyanCatherine Stanton
Jun 28, 2018·The Journal of Endocrinology·Paolo ComeglioLinda Vignozzi
Oct 3, 2018·Nutrition and Cancer·Mark F McCarty, James J DiNicolantonio
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Agostino Di CiaulaPiero Portincasa
Mar 28, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Xin-Hua WangJun Pu
Feb 2, 2021·World Journal of Clinical Cases·Rou ZhangYing-Li He
Feb 27, 2021·Progress in Lipid Research·Stefano FiorucciMichele Biagioli
Apr 4, 2021·International Journal of Molecular Sciences·Giuseppe ManninoCarla Gentile
Apr 15, 2021·Expert Opinion on Drug Discovery·Stefano FiorucciEleonora Distrutti
Jan 13, 2018·Gene Expression·John Y L Chiang, Jessica M Ferrell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved