A role of the thymus and thymosin-alpha1 in brain NGF levels and NGF receptor expression

Journal of Neuroimmunology
P TurriniL Aloe

Abstract

Using neonatal rats we investigated the role of the thymus and thymosin-alpha1 (T-alpha1) in brain NGF levels, NGF receptor (p75NGFr) expression, as well as the activity of choline acetyl-transferase, a cholinergic enzyme regulated by NGF. It is shown that early postnatal thymectomy causes a decrease in NGF in the hippocampus and cortex and p75NGFr distribution in the basal forebrain cholinergic neurons (FBCN). Intracerebral T-alpha1 injection in thymectomized animals induces a recovery, albeit not complete, of both NGF and p75NGFr. These findings indicate that thymectomy affects both the brain NGF producing and responding cells and that T-alpha1 may be one of the thymic hormones involved in the regulation of cerebral NGF synthesis.

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Citations

Dec 31, 2003·Journal of Neuroimmunology·Barbara StampachiacchiereLuigi Aloe
Oct 19, 1999·Neurochemistry International·P Turrini, L Aloe
Jun 1, 2008·Biologics : Targets & Therapy·Maria J Miguez-BurbanoJoel Fishman
Apr 23, 2004·Expert Opinion on Biological Therapy·Allan L Goldstein, Mahnaz Badamchian
Jun 26, 1999·Microscopy Research and Technique·L AloeF Properzi
Nov 26, 2020·International Journal of Molecular Sciences·Rita RezzaniLuigi Fabrizio Rodella

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