A role of WT1 in cell division and genomic stability

Cell Cycle
Jayasha Shandilya, Stefan G E Roberts

Abstract

Wilms' tumor-1 protein (WT1) is a transcription factor that can either activate or repress genes to regulate cell growth, apoptosis and differentiation. WT1 can act as either a tumor suppressor or an oncogene. The cellular functions of WT1 are predominantly regulated by its various interacting partners. Recently we have found that WT1 can regulate the fidelity of chromosome segregation through its interaction with the spindle assembly checkpoint protein, Mitotic arrest deficient-2 (MAD2). WT1 delays anaphase entry by inhibiting the ubiquitination activity of the Anaphase promoting complex/cyclosome (APC/C). Our findings have revealed an important role of WT1 in the regulation of mitotic checkpoint and genomic stability.

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Citations

Mar 23, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Sanda AlexandrescuSara O Vargas
Sep 24, 2019·Molecular Medicine Reports·Zhuo SunYongping Wu
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Jun 25, 2016·Cell Cycle·Jayasha ShandilyaStefan G E Roberts
Feb 13, 2021·Advances in Biological Regulation·Gisele O L RodriguesScott K Durum

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Methods Mentioned

BETA
sumoylation

Related Concepts

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Apoptosis

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