A rolling-horizon pharmacokinetic pharmacodynamic model for warfarin inpatients in transient clinical states

Personalized Medicine
Yao ZhaoKathleen T Hickey

Abstract

To design a pharmacokinetic pharmacodynamic model to make individualized and adaptive international normalized ratio (INR) predictions for warfarin inpatients in changing clinical status. We tested a new model on 60 inpatients at Columbia University. The model personalizes four submodels and minimizes the number of parameters to be estimated. Prediction accuracy was assessed by prediction error, absolute prediction error and percentage absolute prediction error. The INRs were accurately predicted 5 days into the future. Median prediction error: 0.01-0.12; median absolute prediction error: 0.17-0.5 and median percentage absolute prediction error: 9.85-26.06%. Patients exhibit interindividual and intertemporal variability. The model captures the variability and provides accurate and personalized INR predictions.

References

May 1, 1987·Journal of General Internal Medicine·R H WhiteR W Coleman
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·L B Sheiner, S L Beal
Oct 24, 2000·The American Journal of Medicine·B F GageR H White
Jul 26, 2003·QJM : Monthly Journal of the Association of Physicians·E A J Knijff-DutmerM A F J Van de Laar
Dec 24, 2003·Thrombosis and Haemostasis·Karen N van DijkJacobus R B J Brouwers
May 5, 2005·Journal of Thrombosis and Haemostasis : JTH·E PasterkampJ P M Vanderschoot
May 21, 2005·American Journal of Physical Medicine & Rehabilitation·Raj MitraDavid T Burke
Apr 14, 2006·Expert Opinion on Drug Safety·Edith A NutescuPatricia West
Apr 3, 2007·Journal of General Internal Medicine·Carl van Walraven, Alan J Forster
Jul 11, 2007·Archives of Internal Medicine·Diane K WysowskiLynette Swartz
Jan 17, 2008·Chest·Samuel G JohnsonDaniel M Witt
Mar 7, 2008·The New England Journal of Medicine·Ute I SchwarzC Michael Stein
Nov 6, 2008·Journal of Thrombosis and Haemostasis : JTH·A J RoseE M Hylek
May 15, 2009·Blood·Daniel M WittUNKNOWN Warfarin Associated Research Projects and other EnDeavors (WARPED) Consortium
Apr 20, 2010·Journal of Thrombosis and Haemostasis : JTH·D M WittUNKNOWN Warped Consortium
Feb 9, 2011·Pharmaceutical Research·Daniel F B Wright, Stephen B Duffull
Mar 23, 2011·British Journal of Haematology·Martina TeichertLoes E Visser
Jan 19, 2013·Clinical Pharmacokinetics·Daniel F B Wright, Stephen B Duffull
Jan 23, 2013·Circulation·Jason S ChinitzValentin Fuster
Jan 5, 2014·Journal of Clinical Pharmacy and Therapeutics·J W Cheng, G Barillari
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Feb 1, 2007·Personalized Medicine·Kristen K ReynoldsMark W Linder

❮ Previous
Next ❯

Software Mentioned

Excel
Visual Studio

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved