A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet

Calcified Tissue International
Hyang Mok OkOran Kwon

Abstract

The aim of this study was to evaluate the effects of a supplement containing Pueraria lobata/Rehmannia glutinosa (PR) root extracts on bone turnover in ovariectomized (OVX) rats (a model for postmenopausal osteoporosis). Female Sprague-Dawley rats (8 weeks old) were randomized into eight groups: sham-operated rats with low-fat control diet + vehicle, OVX rats with low-fat control diet + vehicle, OVX rats with high-fat diet (HFD) + vehicle, OVX rats with HFD + vehicle + exercise, OVX rats with HFD + PR (400 mg/kg body weight/day p.o.), OVX rats with HFD + PR + exercise, OVX rats with HFD + 17β-estradiol (0.5 mg/kg body weight/day p.o.), OVX rats with HFD + 17β-estradiol + exercise. Bone microarchitecture, bone turnover markers (e.g., plasma alkaline phosphatase and osteocalcin), expressions of osteogenic and resorptive gene markers in the bone were measured. Eight weeks of PR and/or aerobic exercise improved cortical microarchitecture of the femur and decreased markers of bone turnover and expression of skeletal osteoclastogenic genes in the femur. PR supplementation combined with exercise preserved bone loss induced by estrogen deficiency and should be investigated further as an alternative to hormone replacement therapy for pr...Continue Reading

References

Dec 1, 1991·Bone and Mineral·D N Kalu
Jun 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P D DelmasC Christiansen
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N F RayL J Melton
Jul 31, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Brzezinski, A Debi
Sep 1, 2000·Science·S L Teitelbaum
Feb 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P D DelmasUNKNOWN Committee of Scientific Advisors of the International Osteoporosis Foundation]
Aug 11, 2001·Free Radical Biology & Medicine·N ModyL L Demer
Jan 5, 2002·Journal of Physiological Anthropology and Applied Human Science·D NakajimaF Ohta
Jan 11, 2002·Advances in Experimental Medicine and Biology·A LaibS Majumdar
Jul 16, 2002·JAMA : the Journal of the American Medical Association·James V LaceyCatherine Schairer
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kwi Ok OhJung Keun Kim
Aug 21, 2003·Lancet·Valerie Beral, UNKNOWN Million Women Study Collaborators
Apr 8, 2004·Toxicology Letters·Alexandra Alves-Rodrigues, Andrew Shao
Aug 26, 2006·Journal of Pharmaceutical and Biomedical Analysis·Wichai CherdshewasartWinai Dahlan
Jan 11, 2007·Menopause : the Journal of the North American Menopause Society·Ellen M EvansDennis T Villareal
Sep 6, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lan-Juan ZhaoHong-Wen Deng
Dec 25, 2007·Gender Medicine·Piet Geusens, Geertjan Dinant
Apr 9, 2008·Archives of Biochemistry and Biophysics·Brendan F Boyce, Lianping Xing
Dec 23, 2008·Nature Clinical Practice. Rheumatology·Chad Deal
Feb 5, 2009·Critical Reviews in Eukaryotic Gene Expression·Yasuhiro KobayashiNaoyuki Takahashi
Aug 11, 2012·Journal of Nutritional Science and Vitaminology·Seiwa MichiharaYukio Kawamura

❮ Previous
Next ❯

Citations

Feb 15, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yoon Hee LeeHocheol Kim
Jul 5, 2019·Current Stem Cell Research & Therapy·Xiaobin YangLingbo Kong
Feb 6, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W-J ChenT-Y Tsai
Aug 30, 2016·World Journal of Gastroenterology : WJG·Hong YaoJin-Yong Peng
May 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dasom NohOran Kwon
Dec 9, 2020·Trends in Endocrinology and Metabolism : TEM·Daniele BellaviaGianluca Giavaresi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Dong Wook Lim, Yun Tai Kim
Journal of Bone and Mineral Metabolism
Xinxiang WangYoshiko Ishimi
© 2021 Meta ULC. All rights reserved