A ROS-responsive polymeric micelle with a π-conjugated thioketal moiety for enhanced drug loading and efficient drug delivery

Organic & Biomolecular Chemistry
Changzhen SunBin He

Abstract

As the implications of reactive oxygen species (ROS) are elucidated in many diseases, ROS-responsive nanoparticles are attracting great interest from researchers. In this work, a ROS sensitive thioketal (TK) moiety with a π-conjugated structure was introduced into biodegradable methoxy poly(ethylene glycol)-thioketal-poly(ε-caprolactone)mPEG-TK-PCL micelles as a linker, which was designed to speed up the drug release and thus enhance the therapeutic efficacy. The micelle showed a high drug loading content of 12.8% and excellent stability under physiological conditions because of the evocation of π-π stacking and hydrophobic interactions with the anticancer drug doxorubicin (DOX). The polymeric micelle presented a better drug carrier capacity and higher in vitro anticancer efficacy towards cancer cells. The in vivo study showed that DOX-loaded mPEG-TK-PCL micelles displayed lower toxicity towards normal cells and remarkably enhanced antitumor efficacy. This research provides a way to design potential drug carriers for efficient cancer chemotherapy.

References

Jul 25, 2003·Chemical Communications : Chem Comm·Elizabeth R Gillies, Jean M J Fréchet
Mar 3, 2004·Nature Materials·Alessandro NapoliJeffrey A Hubbell
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xintao ShuaiJinming Gao
Mar 18, 2009·Journal of the American Chemical Society·Akamol KlaikherdS Thayumanavan
Sep 11, 2010·ACS Nano·Jagadis SankaranarayananAdah Almutairi
Jun 7, 2013·Advanced Materials·Jinqiang WangZhongwei Gu
Jun 15, 2013·Chemical Society Reviews·Jiaming ZhuangS Thayumanavan
Feb 20, 2014·Colloids and Surfaces. B, Biointerfaces·Mengtan CaiXianglin Luo
Mar 20, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Li LiuLuo Ting Yu
May 9, 2014·Chemical Communications : Chem Comm·Carmen Alvarez-Lorenzo, Angel Concheiro
Jun 21, 2014·Chemical Society Reviews·Rong TongJianjun Cheng
Aug 26, 2014·Chemical Communications : Chem Comm·Shi-Ying LiXian-Zheng Zhang
Dec 6, 2014·Advanced Functional Materials·Yucai WangYounan Xia
Feb 13, 2015·Chemical Communications : Chem Comm·Xin DengBin He
Mar 26, 2015·Chemical Communications : Chem Comm·Wei CaoHuaping Xu
Aug 26, 2015·Chemical Communications : Chem Comm·Chunpo GeJianguo Fang
Feb 7, 2016·Colloids and Surfaces. B, Biointerfaces·Xinfeng ChengWuhou Fan
Mar 24, 2016·Chemical Communications : Chem Comm·Xing WangDecheng Wu
Sep 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yusi LaiZhongwei Gu
Mar 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Elizabeth A RainboltMihaela C Stefan
Jul 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qing LiXin Xu

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Citations

Mar 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hattie C SchunkLaura J Suggs
Sep 8, 2020·Advanced Healthcare Materials·Dandan LiJun Wu
Aug 30, 2018·Biomaterials Research·Saji UthamanIn-Kyu Park
Oct 25, 2020·Drug Delivery·Hongli YuYong Sun
Dec 15, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wan-Ru ZhuangYu-Kyoung Oh
Jul 3, 2020·Colloids and Surfaces. B, Biointerfaces·Qingqing PanBin He
Feb 5, 2021·International Journal of Nanomedicine·Xuan ShaJingjing Li
Dec 18, 2020·Frontiers in Molecular Biosciences·Xiaoliang ChengWei-En Yuan
May 25, 2021·Journal of Biomaterials Science. Polymer Edition·Honglei GuoXiangchun Shen
Jun 20, 2021·Macromolecular Bioscience·Yining NiuYao Fu
Aug 19, 2020·Journal of Agricultural and Food Chemistry·Ruixin LiHeng Yin
Sep 18, 2021·International Journal of Pharmaceutics·Xiuru Yang, Yan Xie

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Methods Mentioned

BETA
nuclear magnetic resonance
dynamic light scattering
fluorescence spectroscopy
flow cytometry
Fluorescence
Confocal microscopy

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