A Sabin 2-related poliovirus recombinant contains a homologous sequence of human enterovirus species C in the viral polymerase coding region

Archives of Virology
Yong ZhangWenbo Xu

Abstract

A type 2 vaccine-related poliovirus (strain CHN3024), differing from the Sabin 2 strain by 0.44% in the VP1 coding region was isolated from a patient with vaccine-associated paralytic poliomyelitis. Sequences downstream of nucleotide position 6735 (3D(pol) coding region) were derived from an unidentified sequence; no close match for a potential parent was found, but it could be classified into a non-polio human enteroviruses species C (HEV-C) phylogeny. The virus differed antigenically from the parental Sabin strain, having an amino acid substitution in the neutralizing antigenic site 1. The similarity between CHN3024 and Sabin 2 sequences suggests that the recombination was recent; this is supported by the estimation that the initiating OPV dose was given only 36-75 days before sampling. The patient's clinical manifestations, intratypic differentiation examination, and whole-genome sequencing showed that this recombinant exhibited characteristics of neurovirulent vaccine-derived polioviruses (VDPV), which may, thus, pose a potential threat to a polio-free world.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J C de la TorreJ J Holland
Mar 1, 1989·Journal of Virology·G D WestropG C Schild
Oct 1, 1981·The Journal of General Virology·O M KewJ F Obijeski
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A NomotoN Imura
Dec 1, 1993·Biologicals : Journal of the International Association of Biological Standardization·P D MinorJ W Almond
Oct 1, 1995·Journal of Clinical Microbiology·H G van der AvoortA M van Loon
Feb 1, 1997·The Journal of Infectious Diseases·K a WangZ Wang
Sep 17, 1998·Journal of Clinical Microbiology·O M KewM A Pallansch
Apr 19, 2002·The Journal of General Virology·Hiromu YoshidaTatsuo Miyamura
Aug 6, 2003·Emerging Infectious Diseases·Dominique RoussetFrancis Delpeyroux
Aug 22, 2003·Reviews in Medical Virology·Walter R DowdleDavid J Wood
Mar 3, 2004·Journal of Virology·M Steven ObersteMark A Pallansch
Nov 27, 2004·Journal of Virology·Hiroyuki ShimizuTatsuo Miyamura
Nov 27, 2004·Journal of Virology·Javier MartínPhilip D Minor
Dec 14, 2004·Journal of Medical Microbiology·Albert Heim
Sep 13, 2005·Annual Review of Microbiology·Olen M KewMark A Pallansch
Aug 10, 2006·The Journal of Infectious Diseases·Xiaofeng LiangJingjin Yu
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
May 26, 2007·Virology Journal·Marion S FreistadtKaren E Eberle
Aug 8, 2007·Virus Genes·Eleni PaximadiPanayotis Markoulatos
Nov 27, 2007·Virus Research·Shih-Chen HuangJen-Ren Wang
Dec 19, 2007·PLoS Pathogens·Mala Rakoto-AndrianariveloFrancis Delpeyroux
Jan 18, 2008·The Journal of Infectious Diseases·Concepción F EstívarizSholah Imari
Apr 19, 2008·The Journal of Infectious Diseases·Mala Rakoto-AndrianariveloJean-Marc Reynes
Nov 4, 2008·Emerging Infectious Diseases·Ana AvellónGloria Trallero

❮ Previous
Next ❯

Citations

Sep 21, 2011·PloS One·Maël BessaudFrancis Delpeyroux
Jul 10, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J-L BaillyH Peigue-Lafeuille

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.