A safety profile of medications used to treat Waldenström's macroglobulinemia

Expert Opinion on Drug Safety
Ramón García-SanzMaría Eugenia Sarasquete

Abstract

Waldenström's macroglobulinemia (WM) is a B-cell lymphoproliferative disease with serum IgM monoclonal component and bone marrow infiltration by lymphoplasmacytic lymphoma. Traditional therapy was based on that regimens used for closely related entities, such as chronic lymphocytic leukemia or multiple myeloma. This resulted in a lack of drugs specifically approved for WM, until the discovery of the Bruton Tyrosine Kinase (BTK) inhibitors. Two main therapeutic attitudes are possible: (1) conventional therapies based on combinations with alkylating agents or proteasome inhibitors with steroids and anti-CD20 monoclonal antibodies or (2) new approaches with BTK inhibitors, usually alone. Other possibilities such as BCL2 inhibitors, PI3K/AKT inhibitors, and others are currently under evaluation, but we will focus the review on the most consolidated approaches that are available for patients with WM at different stages of the disease. PubMed, Web of Science, and clinicaltrials.gov were queried for the keywords 'Waldenstrom macroglobulinemia' and the different drugs here evaluated through 1 February 2018. Although WM has no many specific drugs, there are many possible therapies, including Ibrutinib, the first formally approved drug f...Continue Reading

References

Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V LeblondN Fort
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A DimopoulosP Panayiotidis
Dec 12, 2001·British Journal of Haematology·R García-SanzUNKNOWN Spanish Group for the Study of Waldenström Macroglobulinaemia and PETHEMA (Programme for the Study and Treatment of Haematol
Apr 30, 2003·Seminars in Oncology·Constantine S MitsiadesKenneth C Anderson
Sep 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S P TreonK C Anderson
Mar 30, 2005·Clinical Lymphoma·Steven P TreonAndrew R Barnagan
Apr 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra J StraussT Andrew Lister
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Athanasios AnagnostopoulosSergio A Giralt
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine I ChenUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 10, 2007·Leukemia Research·K J PhekooUNKNOWN South Thames Haematology Specialist Committee
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven P TreonAshraf Badros
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Meletios Athanasios DimopoulosGerasimos Pangalis
Mar 13, 2008·Blood·Xavier LeleuIrene M Ghobrial
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Asher Chanan-KhanPaul G Richardson
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Meletios Athanasios DimopoulosSteven P Treon
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xavier LeleuSteven P Treon
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven P TreonKenneth C Anderson
Apr 14, 2009·Clinical Lymphoma & Myeloma·Leukothea IoakimidisSteven P Treon
Jun 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven P TreonIrene M Ghobrial
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irene M GhobrialPaul G Richardson
Feb 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Irene M GhobrialJeffrey Matous
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charalampia KyriakouNorbert Schmitz
Oct 20, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charalampia KyriakouNorbert Schmitz
Nov 19, 2010·Expert Review of Hematology·Ramón García-Sanz, Enrique M Ocio
May 1, 2010·The Canadian Journal of Hospital Pharmacy·UNKNOWN Pharmacist Prescribing Task Force
Aug 11, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Irene M GhobrialVeronique Leblond
Aug 31, 2012·The New England Journal of Medicine·Steven P TreonZachary R Hunter
Dec 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Véronique LeblondRoger G Owen
Jun 21, 2013·The New England Journal of Medicine·Michael L WangKristie A Blum
Jan 24, 2014·The New England Journal of Medicine·Ajay K GopalGilles A Salles

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Sep 29, 2020·Recent Patents on Anti-cancer Drug Discovery·Romeo G Mihăilă

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