A safety study of 500 μA cathodal transcranial direct current stimulation in rat

BMC Neuroscience
Keying ZhangGuirong Ding

Abstract

Transcranial direct current stimulation (tDCS) is a noninvasive neural control technology that has become a research hotspot. To facilitate further research of tDCS, the biosafety of 500 μA cathodal tDCS, a controversial parameter in rats was evaluated. 24 animals were randomly divided into two groups: a cathodal tDCS group (tDCS, n = 12) and control group (control, n = 12). Animals in the tDCS group received 5 consecutive days of cathodal tDCS (500 μA, 15 min, once per day) followed by a tDCS-free interval of 2 days and 5 additional days of stimulation, totally two treatments of tDCS for a total of 10 days. Computational 3D rat model was adopted to calculate the current density distributions in brain during tDCS treatment. Essential brain functions including motor function and learning and memory ability were evaluated. Additionally, to estimate the neurotoxicity of tDCS, the brain morphology, neurotransmitter levels and cerebral temperature were investigated. Our results showed that the current density inside the brain was less than 20 A/m2 during tDCS treatment in computational model. tDCS did not affect motor functions and learning and memory ability after tDCS treatment. In addition, no significant differences were found f...Continue Reading

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Citations

May 14, 2020·BMC Neuroscience·Ke-Ying ZhangGui-Rong Ding
Mar 13, 2021·International Review of Psychiatry·Rachel WoodhamCynthia H Y Fu

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Software Mentioned

Noldus Ethovision XT
SPSS
SmartView

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