Apr 2, 2020

A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity

BioRxiv : the Preprint Server for Biology
M. YarmarkovichJohn M Maris

Abstract

Here we propose a vaccination strategy for SARS-CoV-2 based on identification of both highly conserved regions of the virus and newly acquired adaptations that are presented by MHC class I and II across the vast majority of the population, are highly dissimilar from the human proteome, and are predicted B cell epitopes. We present 65 peptide sequences that we expect to result in a safe and effective vaccine which can be rapidly tested in DNA, mRNA, or synthetic peptide constructs. These include epitopes that are contained within evolutionarily divergent regions of the spike protein reported to increase infectivity through increased binding to the ACE2 receptor, and within a novel furin cleavage site thought to increase membrane fusion. This vaccination strategy specifically targets unique vulnerabilities of SARS-CoV-2 and should engage a robust adaptive immune response in the vast majority of the human population.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Computer Software
Genome-Wide Association Study
Hordeum vulgare antigen
Genome
Genes
Genome Assembly Sequence
Recombination, Genetic
Nucleic Acid Sequencing
Aegilops tauschii
Genomics

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

American Journal of Clinical Pathology
Ahmed BabikerJeannette Guarner
The New England Journal of Medicine
Xiaoxia LuChinese Pediatric Novel Coronavirus Study Team
Journal of Medical Virology
Beuy Joob, Viroj Wiwanitkit
© 2020 Meta ULC. All rights reserved