A scaling transformation for classifier output based on likelihood ratio: applications to a CAD workstation for diagnosis of breast cancer.

Medical Physics
Karla HorschYulei Jiang

Abstract

The authors developed scaling methods that monotonically transform the output of one classifier to the "scale" of another. Such transformations affect the distribution of classifier output while leaving the ROC curve unchanged. In particular, they investigated transformations between radiologists and computer classifiers, with the goal of addressing the problem of comparing and interpreting case-specific values of output from two classifiers. Using both simulated and radiologists' rating data of breast imaging cases, the authors investigated a likelihood-ratio-scaling transformation, based on "matching" classifier likelihood ratios. For comparison, three other scaling transformations were investigated that were based on matching classifier true positive fraction, false positive fraction, or cumulative distribution function, respectively. The authors explored modifying the computer output to reflect the scale of the radiologist, as well as modifying the radiologist's ratings to reflect the scale of the computer. They also evaluated how dataset size affects the transformations. When ROC curves of two classifiers differed substantially, the four transformations were found to be quite different. The likelihood-ratio scaling transfo...Continue Reading

References

Oct 1, 1978·Seminars in Nuclear Medicine·C E Metz
Apr 1, 1978·Perception & Psychophysics·J A SwetsJ B Swets
Jan 1, 1992·Medical Decision Making : an International Journal of the Society for Medical Decision Making·C E Metz, J H Shen
Mar 1, 1990·Investigative Radiology·H E RocketteC E Metz
Sep 1, 1986·Investigative Radiology·C E Metz
Oct 1, 1986·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J G DolanA I Mushlin
May 1, 1993·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M L GigerX Chen
Jan 19, 1999·Academic Radiology·Y JiangK Doi
May 18, 1999·Journal of Mathematical Psychology·C E Metz, X Pan
Jun 1, 1949·Biometrika·M G KENDALL
Mar 20, 2008·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrea Gurmankin Levy, John C Hershey

❮ Previous
Next ❯

Citations

May 21, 2013·Annual Review of Biomedical Engineering·Maryellen L GigerJulia A Schnabel
Aug 11, 2016·Statistical Methods in Medical Research·Weijie ChenNicholas Petrick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.