PMID: 45537Jan 1, 1975

A schizophreniform behavioral psychosis mediated by dopamine

The American Journal of Psychiatry
D L GarverJ M Davis

Abstract

The authors conducted a study in which schizophrenic-like behavioral disturbances were induced in members of a macaque social colony by the chronic administration of d-amphetamine. Animals given the drug showed hypervigilance, hyperactivity, fragmented and repetitive behaviors, and progressive social withdrawal as well as the development of solitary stereotypies. The syndrome was dissected pharmacologically with alpha-methyl-para-tyrosine, chlorpromazine, pimozide, and haloperidol. Based on the behavioral findings and the known mechanisms of action of these drugs, the authors conclude that the major elements of the psychotic-like behavior induced by d-amphetamine were mediated by dopamine systems.

References

Jan 1, 1976·Annals of the New York Academy of Sciences·K R Carlson, R D Eibergen
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Feb 1, 1982·Psychological Medicine·R M Ridley, H F Baker
Oct 21, 2006·Journal of Computer-aided Molecular Design·Sandhya Kortagere, William J Welsh
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Related Concepts

Trichohepatoenteric Syndrome
Antipsychotic Effect
Assay OF Haloperidol
Oxydess
Schizophrenia
Haloperidol
Dopamine Measurement
Dopamine
Chlorpromazine
Pimozide

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