A scoping review on medication adherence in older patients with cognitive impairment or dementia

Research in Social & Administrative Pharmacy : RSAP
Zain K Hudani, Carlos H Rojas-Fernandez

Abstract

Cognitive impairment is common in older patients, many of whom receive multiple and complex medication regimens. Such patients are at high risk for medication non-adherence. Limited information exists regarding adherence in this population. A scoping review was conducted to explore aspects of medication adherence in this population. A comprehensive search of MEDLINE, EMBASE, CINAHL, IPA and Psychinfo was conducted during 1966 to January 2015. Arksey and O'Malley's framework for scoping reviews was utilized. From an initial 582 citations, 42 research papers and 2 conference proceedings were eligible for review. The prevalence of non-adherence ranged from 2% to 59%. The most common assessment tool was self-reported adherence (32%). Barriers to adherence were cognitive impairment, non-Caucasian race, poor communication with prescribers, lack of social support, and increased pill burden. Interventions to improve adherence included alternate dosage forms, and multi-compartment pillboxes. Additional research is needed to address various gaps in the literature such as studies describing the effects of cognitively impaired caregivers on patient's medication adherence, the comparative effectiveness of different adherence enhancing strat...Continue Reading

References

Jul 1, 1996·Journal of the American Geriatrics Society·L BoucherJ E Jackson
Jun 26, 2001·British Journal of Clinical Pharmacology·I BaratE M Damsgaard
Oct 23, 2002·Pharmacotherapy·Cynthia L RaehlRebecca B Sleeper
Dec 12, 2003·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Sabina De Geest, Eduardo Sabaté
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Nov 4, 2005·The New England Journal of Medicine·Ronald J Campbell
Nov 22, 2005·Applied Nursing Research : ANR·Kathleen Collins Insel, Lois Cole
May 4, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Mary GanguliHiroko H Dodge
Jul 25, 2006·The American Journal of Geriatric Pharmacotherapy·Lisa C HutchisonJeanne Y Wei
Oct 26, 2006·Journal of Gerontological Social Work·Victoria CotrellTheresa Bader
May 31, 2007·American Journal of Alzheimer's Disease and Other Dementias·Glenn E SmithKristin S Vickers
Nov 22, 2008·Drugs & Aging·Sönke ArltWolfgang von Renteln-Kruse
Apr 3, 2009·Journal of Aging and Health·Tamara L HayesJeffrey A Kaye
Jun 15, 2010·Expert Opinion on Pharmacotherapy·Nazem BassilGeorge T Grossberg
Sep 22, 2010·Implementation Science : IS·Danielle LevacKelly K O'Brien
Jan 14, 2011·British Journal of Health Psychology·Anthony JerantPeter Franks
Feb 18, 2012·International Journal of Geriatric Psychiatry·Thulasi ThiruchselvamMary C Tierney
Jun 5, 2012·The American Journal of Geriatric Pharmacotherapy·Noll L CampbellMichael D Murray
Jun 29, 2012·American Journal of Alzheimer's Disease and Other Dementias·Tomoko KamimuraTakenobu Inoue
Sep 7, 2012·Australasian Journal on Ageing·David G Le CouteurAndrew J McLachlan
Nov 2, 2012·Psychosomatic Medicine·Michael L AloscoJohn Gunstad
Jan 5, 2013·Journal of General Internal Medicine·Ian M KronishCarol R Horowitz
Oct 12, 2013·Alzheimer Disease and Associated Disorders·Bernhard HaiderChristian Lampl
Oct 30, 2013·International Journal of Clinical Pharmacy·Audrey LehmannMarie Paule Schneider

❮ Previous
Next ❯

Citations

Jun 21, 2017·Current Opinion in Psychiatry·Antje D ArltWinfried Rief
Jul 12, 2018·Expert Opinion on Drug Safety·Tesfahun C EshetieLisa M Kalisch Ellett
Nov 23, 2018·Breast Cancer Research and Treatment·Cole B HaskinsElizabeth A Chrischilles
Feb 6, 2017·Journal of Internal Medicine·A SubicS Garcia-Ptacek
Sep 25, 2018·Expert Opinion on Pharmacotherapy·Amanda CalhounGeorge T Grossberg
Oct 5, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xiaoyan LengSally A Shumaker
Jul 3, 2021·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Sayuri SuwaAtsuko Shimamura
Aug 17, 2021·Journal of Diabetes Research·Michelle Asiedu-DansoAugustina Koduah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.