A scoring system for the classification of CD5-B CLL versus CD5+ B CLL and B PLL

Leukemia & Lymphoma
F Salomon-NguyenG Flandrin

Abstract

B CLL is a monoclonal proliferation of lymphocytes which express the CD5 antigen (CD5+ CLL). Rare exceptions (less than 10%) are CD5-, as are the majority of B PLL. We have studied the clinical, cytological and immunophenotypic characteristics of a series of 12 CD5-CLL and have established a score which allows the distinction between CD5+ CLL, CD5- CLL and PLL. Among the CD5- CLL, there were significantly more cases with advanced stage (Rai and Binet) and splenomegaly. The cytological study found more mixed CLL according to FAB classification (more prolymphocytes). There were significantly more CD23-, FMC7+, SIg strong positive cases. A score from 0 to 6 was established based on clinical, cytological and immunophenotypic criteria. Typical CD5+ CLL was scored 0, score 6 corresponded to typical PLL. There were significantly more higher scores amongst CD5- CLL. It therefore appears that CD5- CLLs share certain features with B PLL. The use of this scoring system will allow determination of prognosis within these different categories, thus identifying groups which require specific therapy.

References

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Citations

Nov 1, 1996·Leukemia Research·F Salomon-NguyenG Flandrin
Mar 1, 1997·Cancer Genetics and Cytogenetics·J DierlammD K Hossfeld
Jan 12, 2008·American Journal of Hematology·Maria GoldanigaLuca Baldini
Feb 13, 2003·British Journal of Haematology·Georges JungPhilippe Hénon
Aug 31, 2002·Hematological Oncology·Gerassimos A PangalisMaria K Angelopoulou
Aug 1, 2020·The Cochrane Database of Systematic Reviews·Nina KreuzbergerNicole Skoetz
May 6, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Cengiz DemirSenar Ebinç

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