A Search for Blood Biomarkers for Autism: Peptoids

Scientific Reports
Sayed ZamanDwight C German

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of behavior. In order to identify individuals with ASD and initiate interventions at the earliest possible age, biomarkers for the disorder are desirable. Research findings have identified widespread changes in the immune system in children with autism, at both systemic and cellular levels. In an attempt to find candidate antibody biomarkers for ASD, highly complex libraries of peptoids (oligo-N-substituted glycines) were screened for compounds that preferentially bind IgG from boys with ASD over typically developing (TD) boys. Unexpectedly, many peptoids were identified that preferentially bound IgG from TD boys. One of these peptoids was studied further and found to bind significantly higher levels (>2-fold) of the IgG1 subtype in serum from TD boys (n = 60) compared to ASD boys (n = 74), as well as compared to older adult males (n = 53). Together these data suggest that ASD boys have reduced levels (>50%) of an IgG1 antibody, which resembles the level found normally with advanced age. In this discovery study, the ASD1 peptoid was 66% accurate in predicting ASD.

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Citations

Nov 5, 2016·NPJ Parkinson's Disease·Umar YazdaniDwight C German
Aug 19, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amory Meltzer, Judy Van de Water
Sep 25, 2017·Psychiatry and Clinical Neurosciences·Mary M Y Waye, Ho Yu Cheng
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gulce Ogruc IldizRui Fausto
May 7, 2021·Journal of Proteomics·Yan WangGuangtao Yan
Oct 7, 2021·Chemical Communications : Chem Comm·Claudine Nicole HerlanStefan Bräse

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Methods Mentioned

BETA
ELISA
affinity purification
electrophoresis
blood draw

Software Mentioned

R lavaan
GraphPad Prism

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Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

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