A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part VI. Evaluation of the antimalarial activity of plants used by Isoceño-Guaraní Indians

Journal of Ethnopharmacology
Geneviève BourdyEric Deharo

Abstract

Seventy-seven plant extracts (corresponding to 62 different species) traditionally used by the Isoceño-Guaraní, a native community living in the Bolivian Chaco, were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine sensitive strain (F32), and on ferriprotoporphyrin (FP) IX biocrystallisation inhibition test (FBIT). Among these extracts, seven displayed strong in vitro antimalarial activity, and 25 were active in the FBIT test. Positive results on both tests were recorded for six extracts: Argemone subfusiformis aerial part, Aspidosperma quebracho-blanco bark, Castela coccinea leaves and bark, Solanum argentinum leaves and Vallesia glabra bark. Results are discussed in relation with Isoceño-Guaraní traditional medicine. Further studies to be undertaken in relation with these results are also highlighted.

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Citations

Apr 9, 2005·Journal of Ethnopharmacology·M VigneronG Bourdy
May 3, 2007·Journal of Ethnobiology and Ethnomedicine·Alexandros S Botsaris
Dec 20, 2015·Malaria Journal·Renata B S LimaAdrian M Pohlit
Nov 14, 2006·Journal of Ethnopharmacology·M L de MesquitaL S Espindola
Oct 13, 2006·Journal of Ethnopharmacology·Abdolali MohagheghzadehYounes Ghasemi
Mar 7, 2006·Journal of Ethnopharmacology·L P KvistA Gonzalez
Nov 3, 2010·Journal of Ethnopharmacology·Lastenia RuizVincent Roumy
Sep 7, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Geethi PamunuwaViduranga Y Waisundara
Dec 5, 2012·Anais Da Academia Brasileira De Ciências·Maria Fâni DolabelaAlaide B Oliveira
Oct 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Immacolata FaraoneLuigi Milella
Mar 13, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heloisa Alves GuimarãesIvo José Curcino Vieira
Mar 1, 2018·The Journal of Pharmacy and Pharmacology·Dayane P de AraújoGlauce S B Viana
Oct 4, 2020·Applied Biochemistry and Biotechnology·Daniel A González-VelázquezJuan C Ramírez-Suarez
Nov 17, 2019·Food Research International·Gustavo Araujo PereiraGlaucia Maria Pastore

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