A search for protein biomarkers links olfactory signal transduction to social immunity

BMC Genomics
Maria Marta GuarnaLeonard J Foster

Abstract

The Western honey bee (Apis mellifera L.) is a critical component of human agriculture through its pollination activities. For years, beekeepers have controlled deadly pathogens such as Paenibacillus larvae, Nosema spp. and Varroa destructor with antibiotics and pesticides but widespread chemical resistance is appearing and most beekeepers would prefer to eliminate or reduce the use of in-hive chemicals. While such treatments are likely to still be needed, an alternate management strategy is to identify and select bees with heritable traits that allow them to resist mites and diseases. Breeding such bees is difficult as the tests involved to identify disease-resistance are complicated, time-consuming, expensive and can misidentify desirable genotypes. Additionally, we do not yet fully understand the mechanisms behind social immunity. Here we have set out to discover the molecular mechanism behind hygienic behavior (HB), a trait known to confer disease resistance in bees. After confirming that HB could be selectively bred for, we correlated measurements of this behavior with protein expression over a period of three years, at two geographically distinct sites, using several hundred bee colonies. By correlating the expression pat...Continue Reading

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Citations

Oct 17, 2019·Annual Review of Animal Biosciences·Margarita M López-UribeMichael Simone-Finstrom
Feb 16, 2019·Genome Biology and Evolution·Brock A HarpurAmro Zayed
Sep 5, 2019·International Journal of Molecular Sciences·Solomon Zewdu AltayeJianke Li
Apr 11, 2018·Scientific Reports·Alison McAfeeLeonard J Foster
Aug 23, 2017·Scientific Reports·M Marta GuarnaLeonard J Foster
Jul 6, 2018·Frontiers in Physiology·Immacolata IovinellaFrancesca R Dani
Jul 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Qian SunXuguo Zhou
Mar 21, 2018·Journal of Agricultural and Food Chemistry·Zewdu Ararso HoraJianke Li

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Datasets Mentioned

BETA
PXD001616

Methods Mentioned

BETA
chemical treatments
PCR
reversed phase chromatography
gel filtration

Software Mentioned

MultiExperiment Viewer
Mascot
DTASuperCharge
MSQuant
DAVID
R
DAVID ( Database for Annotation , Visualization , and Integrat...

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