Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology
H Stanley ThompsonE S Meek
Serum specimens from a large number of patients with Adie's syndrome were checked for virus antibody levels: Measles hemagglutination inhibition (HI), parainfluenza types I, II and III (HI), Epstein-Barr immunofluorescence, Mumps complement fixation (CF), Adenovirus (CF), Varicella-Zoster (CF), Herpes simplex (CF), Cytomegalovirus (CF), Mycoplasma hominis (CF), Toxoplasma gondii passive hemagglutination. These antibody levels were compared with specimens from a control group of similar age distribution and sex ratio. No statistically significant differences between the patients with Adie's syndrome and the control group could be demonstrated. This observation offers some indirect support to Harriman's idea that Adie's syndrome is not due to a viral ciliary ganglionitis but rather to an indolent neuronal degeneration in the ciliary and dorsal root ganglia.
The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.