A second gene encodes the anti-diuretic hormone in the insect, Rhodnius prolixus

Molecular and Cellular Endocrinology
Jean-Paul Paluzzi, Ian Orchard

Abstract

In the haematophagous insect, Rhodnius prolixus, a rapid diuresis following engorgement of vertebrate blood is under the control of two main diuretic hormones: a corticotropin-releasing factor (CRF)-related peptide andserotonin (5HT). A CAP2b (CAPA)-related peptide is involved in the termination of this diuresis, and we have recently identified a gene, now referred to as RhoprCAPA-alpha, encoding CAPA peptides in R. prolixus. Here we identify a second gene, RhoprCAPA-beta, which also encodes CAPA peptides and characterize its expression in fifth-instar and adults. The RhoprCAPA-beta gene is more highly expressed in the CNS than the RhoprCAPA-alpha gene, but neither gene is expressed in other tested adult tissues. Both genes are expressed in a subset of immunoreactive neurons identified using an antisera which recognizes CAP2b-related peptides. The expression of each paralog is modified by feeding and we propose this to be a result of requirements of anti-diuretic regulation during salt and water homeostasis.

Citations

Sep 17, 2013·Journal of Insect Physiology·Fernanda StaniscuaskiIan Orchard
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jean-Paul PaluzziIan Orchard
Jan 10, 2012·General and Comparative Endocrinology·Jean-Paul V Paluzzi
Nov 26, 2010·Peptides·Geoffrey M Coast, David A Schooley
Oct 21, 2010·Insect Molecular Biology·S OnsR Rivera-Pomar
Oct 22, 2011·Peptides·Reinhard PredelRonald J Nachman
Apr 6, 2013·General and Comparative Endocrinology·Shireen-A DaviesJulian A T Dow
May 24, 2016·Journal of Insect Physiology·Sheila Ons
Apr 22, 2015·PloS One·María José Villalobos-SambucaroJorge Rafael Ronderos
May 6, 2019·The Journal of Experimental Biology·Natalia CapriottiSheila Ons
Nov 24, 2018·Scientific Reports·Andrés LavoreSheila Ons
Aug 23, 2020·Cell and Tissue Research·Dick R Nässel, Meet Zandawala
Nov 18, 2017·Journal of Proteome Research·Reinhard PredelChristian Wegener

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