A SEER-Medicare analysis of the impact of metformin on overall survival in ovarian cancer

Gynecologic Oncology
Christine GarciaLeigh A Cantrell

Abstract

Determine whether metformin use is associated with improved survival in patients with ovarian, fallopian tube or primary peritoneal cancer. All patients with a diagnosis of first epithelial ovarian cancer from 2007 to 2011 in the combined SEER-Medicare database were identified from the SEER registry primary site codes. Comorbidities, procedures and cancer treatment ICD-9 and HCPCS codes were used to search the Medicare claims files. Medication use was determined with National Drug Codes using the Medicare Part D event files. The primary outcome, overall survival, was assessed between metformin users and non-users using a Cox Proportional Hazards survival model. To control for confounding, metformin users were matched to non-metformin users using propensity scores. Effect of dosage on survival was assessed using discrete time survival analysis with pooled logistic regression (PLR). There were 2291 cases that met our inclusion criteria. Of these, 180 (7.9%) had been on metformin. The median age was 73years, with the majority of the population being White (83.5%) and treated with primary surgery (74.1%). Metformin use was not associated with overall survival in the entire cohort (HR 0.96, 95% CI 0.75-1.23) or in the matched sample...Continue Reading

Citations

Jul 25, 2019·Current Pharmaceutical Design·Yongbo WangZhi-Jiang Zhang
May 16, 2020·Journal of the National Cancer Institute. Monographs·Clara J K LamAngela B Mariotto
Jan 15, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jinghua ShiLibo Yang
May 28, 2020·Journal of Personalized Medicine·Stergios BoussiosNicholas Pavlidis
Jun 5, 2021·Journal of Gynecologic Oncology·Jeong Yeol ParkSeonok Kim

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