A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Journal of the American Chemical Society
Fang YuanMatthew Bogyo

Abstract

Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

References

Mar 30, 2001·The Journal of Biological Chemistry·P J WoltersG H Caughey
Jul 4, 2002·Molecular & Cellular Proteomics : MCP·Doron GreenbaumMatthew Bogyo
Nov 5, 2004·International Journal of Paediatric Dentistry·Cristina FrezziniStephen Porter
Dec 24, 2004·The Journal of Biological Chemistry·Elena TchougounovaGunnar Pejler
Jan 13, 2006·Nature Chemical Biology·Daisuke KatoMatthew Bogyo
Jan 13, 2006·Nature Chemical Biology·Galia BlumMatthew Bogyo

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Citations

Jul 18, 2009·ACS Chemical Biology·Aaron W Puri, Matthew Bogyo
Sep 25, 2012·Journal of the American Chemical Society·Hyunil JoDoron C Greenbaum
Jan 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Charng-Sheng TsaiChi-Huey Wong
May 1, 2008·The Journal of Biological Chemistry·Kelly N DuBoisMohammed Sajid
Jul 20, 2010·Future Medicinal Chemistry·Douglas S JohnsonBenjamin F Cravatt
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Edgar DeuMatthew Bogyo
Sep 26, 2013·Genes & Development·Brian RuffellLisa M Coussens
Feb 14, 2016·Plant & Cell Physiology·Kyoko Morimoto, Renier A L van der Hoorn
Aug 11, 2015·Chemistry & Biology·Wouter A van der LindenMatthew Bogyo
Sep 1, 2009·Current Opinion in Chemical Biology·Divya Krishnamurthy, Amy M Barrios
May 15, 2012·The FEBS Journal·Robert Karisch, Benjamin G Neel
Jan 28, 2014·Biotechnology Journal·Hai-Yu HuCarsten Schultz
Apr 16, 2014·Medicinal Research Reviews·Laizhong ChenMinyong Li
Sep 10, 2016·Angewandte Chemie·Nikolaos EleftheriadisFrank J Dekker
Mar 4, 2008·Bioorganic & Medicinal Chemistry·Jun LiJennifer L Harris
Feb 20, 2008·Chembiochem : a European Journal of Chemical Biology·Mahesh UttamchandaniShao Q Yao
May 5, 2020·Chemical Communications : Chem Comm·Yinan SongXiaoyu Li
Mar 22, 2014·Chembiochem : a European Journal of Chemical Biology·Matthias D MertensMichael Gütschow
Sep 26, 2012·Chembiochem : a European Journal of Chemical Biology·D Alexander ShannonEranthie Weerapana
Feb 6, 2015·Chembiochem : a European Journal of Chemical Biology·Pengyu Yang, Kai Liu
Mar 21, 2012·ChemMedChem·Sevnur SerimSteven H L Verhelst
May 18, 2021·Frontiers in Chemistry·Paulina Kasperkiewicz
Jan 14, 2012·Journal of the American Chemical Society·Ta-Chun ChengYu-Ling Leu
Aug 12, 2009·Bioorganic & Medicinal Chemistry Letters·Daniel GuayM David Percival

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