A selective concentration-dependent dysrhythmogenic and antidysrhythmic action of prostaglandins E2, F2 alpha and I2 (prostacyclin) on isolated rat hearts

M Karmazyn, N S Dhalla


Prostaglandins (PGs) E2, F2 alpha and I2 were examined for their effects on the electrical and mechanical activities of isolated rat, rabbit and guinea-pig hearts. All PGs produced dysrhythmias in rat hearts at low concentrations only, while higher concentrations were antiarrhythmic. Guinea-pig hearts were less responsive while rabbit hearts were completely resistant.


Nov 1, 1983·Basic Research in Cardiology·U N Das
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·P L BarringtonP Rosenberg
Aug 1, 1983·Prostaglandins, Leukotrienes, and Medicine·W SziegoleitW Förster
Apr 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M C AuclairP Lechat
Nov 1, 1981·Prostaglandins and Medicine·H J Mest, W Förster
Oct 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I KanzikH Zengil
May 17, 2017·Pediatric Cardiology·Safwat A AlyHoang H Nguyen

Related Concepts

Cardiac Arrhythmia
Dose-Response Relationship, Drug
Prostaglandins E
Prostaglandins F
Chinchilla Rabbits
Rats, Laboratory

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