PMID: 3767489Nov 1, 1986Paper

A self-sealing dialysis prosthesis. Coaxial double PTFE-silicone graft

Annals of Surgery
H SchanzerE C Peirce


The performance of a new dialysis prosthesis designed to self-seal after puncture was tested ex vivo and in vivo. It consists of two coaxial polytetrafluoroethylene tubes (PTFE), the space between them filled with silicone rubber sealant (PTFE-sil). Ex vivo: Three PTFE-sil, three double PTFE (without silicone), and three single PTFE grafts were placed sequentially between scribner shunts in the hind limb of four dogs. Bleeding on puncturing with an 18-gauge needle was measured for 30 seconds. PTFE-sil bled less than the controls (g): PTFE-sil; 16 +/- 18; double PTFE: 32 +/- 10; single PTFE: 52 +/- 19 (p less than 0.001). In vivo: Six PTFE-sil and five single PTFE grafts were interposed between the carotid artery and jugular vein of dogs and were punctured with a 16-gauge needle on days 1, 3, and 7. Bleeding was measured through an incision over the puncture site at 5 minutes. In 11 punctures of PTFE-sil, there was no bleeding; three bled less than 20 g. In 13 control punctures, none bled less than 70 g. Patency: Grafts were studied for patency in arteriovenous (AV) fistulas in 34 dogs. Each dog received a PTFE-sil graft in one groin and a single PTFE control graft in the other. At 4 months, patency rates were: PTFE-sil, 84%; si...Continue Reading


Jan 1, 1979·Annals of Surgery·V A TellisF J Veith
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Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·J L ChinitzC Swartz
Nov 17, 1966·The New England Journal of Medicine·M J BresciaB J Hurwich
Nov 1, 1984·Archives of Surgery·J E ConnollyP M McCart
Jul 1, 1980·The British Journal of Surgery·P J GuillouR C Kester

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Aug 1, 1989·American Journal of Surgery·H SchanzerE C Peirce

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