A Semiconducting Polymer Nano-prodrug for Hypoxia-Activated Photodynamic Cancer Therapy

Angewandte Chemie
Dong CuiKanyi Pu

Abstract

Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1 O2 ) under NIR photoirradiation but also specifically activates its chemotherapeutic action in hypoxic tumor microenvironment. SPNpd is self-assembled from a amphiphilic polymer brush, which comprises a light-responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated with a chemodrug through hypoxia-cleavable linkers. The well-defined and compact nanostructure of SPNpd (30 nm) enables accumulation in the tumor of living mice. Owing to these features, SPNpd exerts synergistic photodynamic and chemo-therapy, and effectively inhibits tumor growth in a xenograft tumor mouse model. This study represents the first hypoxia-activatable phototherapeutic polymeric prodrug system with a high potential for cancer therapy.

References

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Citations

Apr 18, 2019·Angewandte Chemie·Yuyan JiangKanyi Pu
Dec 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongliang CaoWeian Zhang
Jan 1, 2020·Chembiochem : a European Journal of Chemical Biology·Xing Qin, Yongsheng Li
Mar 14, 2020·Chemical Communications : Chem Comm·Min Ho ParkHoon Hyun
Jul 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haitao SunXiaolin Wang
Jul 16, 2020·Advanced Materials·Yan ZhangKanyi Pu
Aug 29, 2020·Chemical Communications : Chem Comm·Van-Nghia NguyenJuyoung Yoon
Aug 5, 2020·Journal of Nanobiotechnology·Xiaoying WangZongyu Xie
May 20, 2020·International Journal of Nanomedicine·Weiwei WangLingling Shan
Mar 29, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Dongyang ZhaoJin Sun
Oct 29, 2020·Chemical Society Reviews·Jiajie ChenJianlin Shi
Nov 28, 2020·Chemical Society Reviews·Cheng Xu, Kanyi Pu
Nov 27, 2020·Advanced Healthcare Materials·Miffy Hok Yan ChengGang Zheng
Jan 13, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianren XuHongping Zhou
Jan 15, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Xiaozhen LiChun-Sing Lee
Dec 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weijia LuYi Qi
Aug 28, 2020·Angewandte Chemie·Shiyu ZhouXiabin Jing
Feb 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zongyu XieXiaojing Wang
Feb 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ziqi ZhangYanli Tang
Apr 8, 2020·European Journal of Medicinal Chemistry·Mengjiao ZhouFeifei An

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