PMID: 8962516Oct 1, 1996Paper

A semiparametric approach to risk assessment for quantitative outcomes

Risk Analysis : an Official Publication of the Society for Risk Analysis
R J BoschL Ryan

Abstract

Characterizing the dose-effect relationship and estimating acceptable exposure levels are the primary goals of quantitative risk assessment. A semiparametric approach is proposed for risk assessment with continuously measured or quantitative outcomes which has advantages over existing methods by requiring fewer assumptions. The approach is based on pairwise ranking between the response values in the control group and those in the exposed groups. The work generalizes the rank-based Wilcoxon-Mann-Whitney test, which for the two-group comparison is effectively a test of whether a response from the control group is different from (larger than) a response in an exposed group. We develop a regression framework that naturally extends this metric to model the dose effect in terms of a risk function. Parameters of the regression model can be estimated with standard software. However, inference requires an additional step to estimate the variance structure of the estimated parameters. An effective dose (ED) and associated lower confidence limit (LED) are easily calculated. The method is supported by a simulation study and is illustrated with a study on the effects of aconiazide. The method offers flexible modeling of the dose effect, and...Continue Reading

References

Apr 1, 1992·Regulatory Toxicology and Pharmacology : RTP·D W Gaylor
Dec 1, 1988·Regulatory Toxicology and Pharmacology : RTP·D G Barnes, M Dourson
Mar 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·C A Kimmel, D W Gaylor
Oct 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K S Crump
Aug 1, 1993·Journal of the American College of Nutrition·N B Cummings
Apr 1, 1993·Risk Analysis : an Official Publication of the Society for Risk Analysis·R L Kodell, R W West

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Citations

Aug 12, 2000·International Journal of Food Microbiology·M L Delignette-Muller, L Rosso
Nov 16, 2002·Journal of Toxicology and Environmental Health. Part a·Daniel KrewskiMartha Sinclair
Feb 17, 2000·Annals of the New York Academy of Sciences·R L Kodell, D W Gaylor
Feb 24, 2001·Inhalation Toxicology·D KrewskiK Y Fung
Apr 15, 2000·Risk Analysis : an Official Publication of the Society for Risk Analysis·R W West, R L Kodell
May 21, 2013·Risk Analysis : an Official Publication of the Society for Risk Analysis·Walter W PiegorschLizhen Lin
Sep 7, 2005·Regulatory Toxicology and Pharmacology : RTP·Kim Z TravisZoe K Welsh
Feb 3, 1999·Regulatory Toxicology and Pharmacology : RTP·D GaylorY Zhu
Feb 11, 2005·Journal of Biopharmaceutical Statistics·Walter W PiegorschRalph L Kodell

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