PMID: 2508732May 1, 1989Paper

A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people

Nō to shinkei = Brain and nerve
S KuzuharaH Shimada

Abstract

Submitted for the study were 116 autopsy brains, from 65 non-demented people, 24 patients with dementia of Alzheimer type (DAT) and 27 patients with vascular dementia, aged between 50 s and 100 s. Formalin-fixed, paraffin-embedded coronal sections of the brains at the level of the lateral geniculate body were immunohistochemically stained with the avidin-biotin-peroxidase complex procedure, using the anti-bodies to tau protein purified from human brains (anti-tau) as the primary antibodies. Alzheimer neurofibrillary tangles (NFTs) which were specifically and selectively stained by anti-tau were semiquantitatively counted in the areas of the hippocampus, parahippocampal gyrus and lateral occipitotemporal gyrus. The results were as follows: 1) In non-demented subjects, NFTs in the hippocampus and parahippocampal gyrus were scanty in the 50 s: they increased markedly after 60 years until 90 as the patients' age increased; they tended to decrease over 90 years. In contrast, NFTs in the lateral occipitotemporal gyrus remained none or scanty, always less than 10/mm2 field, throughout the ages between 50 s and 100 s. 2) In DAT cases, NFTs in the hippocampus and parahippocampal gyrus were numerous in all cases at any ages. NFTs in the ...Continue Reading

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