PMID: 6112085Jan 1, 1981Paper

A sensitive technique for determination of thyroid-stimulating immunoglobulin (TSI) in unfractionated serum

Clinical Endocrinology
J Etienne-Decerf, R J Winand

Abstract

A new sensitive and reproducible technique for the determination of thyroid stimulating immunoglobulins is described. This procedure employs cells obtained from primary culture of human thyroid gland. We measured the increase of cyclic AMP after addition of patient sera. The major advantages of this procedure are the improved sampling throughout with the ability to measure eighty samples simultaneously without fractionation of serum. This large sample allows us to test forty sera together and to assay in duplicate, thus increasing the validity of the results. The TSI activity is associated with the immunoglobulins G (IgG) fraction and we obtained a linear dose response curve with IgG as well as with whole serum. The results obtained in various thyroid diseases are discussed.

References

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
May 1, 1984·Allergy·K BechH Nielsen
Nov 1, 1986·Clinical Endocrinology·J M BoutinM Zakarija
Jan 1, 1982·Springer Seminars in Immunopathology·S W ManleyD D Adams
Oct 12, 2007·Journal of Computational Neuroscience·Anna Y Kuznetsova, Richard C Deth
Feb 1, 1986·Australian and New Zealand Journal of Medicine·C R Strakosch
Apr 1, 1987·Journal of Endocrinological Investigation·J R AttaliJ Sebaoun
Jan 2, 1986·Klinische Wochenschrift·E SchifferdeckerK Schöffling
Feb 1, 1990·Clinical Biochemistry·L C Harrison, P J Leedman
Jan 1, 1986·Journal of Cellular Biochemistry·N IslamN R Farid

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