A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2

Cell Host & Microbe
Alba GrifoniAlessandro Sette

Abstract

Effective countermeasures against the recent emergence and rapid expansion of the 2019 novel coronavirus (SARS-CoV-2) require the development of data and tools to understand and monitor its spread and immune responses to it. However, little information is available about the targets of immune responses to SARS-CoV-2. We used the Immune Epitope Database and Analysis Resource (IEDB) to catalog available data related to other coronaviruses. This includes SARS-CoV, which has high sequence similarity to SARS-CoV-2 and is the best-characterized coronavirus in terms of epitope responses. We identified multiple specific regions in SARS-CoV-2 that have high homology to the SARS-CoV virus. Parallel bioinformatic predictions identified a priori potential B and T cell epitopes for SARS-CoV-2. The independent identification of the same regions using two approaches reflects the high probability that these regions are promising targets for immune recognition of SARS-CoV-2. These predictions can facilitate effective vaccine design against this virus of high priority.

Citations

Apr 11, 2020·Physiological Genomics·Rachel M GolonkaMatam Vijay-Kumar
Apr 19, 2020·Journal of Virology·Austin NguyenReid F Thompson
Jun 17, 2020·Expert Review of Respiratory Medicine·Majid Teymoori-RadAlireza Tahamtan
Jul 4, 2020·Journal of Medical Virology·Satarudra Prakash SinghThakur Prasad Yadav
Jun 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sean M Cascarina, Eric D Ross
Aug 19, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Omalla A OlwenyiSiddappa N Byrareddy
Aug 19, 2020·American Journal of Clinical Pathology·Pauline H HerroelenAn-Sofie Decavele
Sep 10, 2020·PloS One·Lluc Farrera-SolerNicolas Winssinger
Sep 24, 2020·Expert Review of Vaccines·Leonard MoiseAnne S De Groot
Sep 10, 2020·Hepatology Communications·Yuval IshayYaron Ilan
May 14, 2020·Allergy·Fariba Karamloo, Renate König
Jul 2, 2020·International Journal of Molecular Sciences·Alejandro LlanesRicardo Lleonart
Jul 25, 2020·Human Vaccines & Immunotherapeutics·Wangxue Chen
Aug 11, 2020·JMIR Bioinformatics and Biotechnology·Sukrit SrivastavaKailash C Pandey
Jul 1, 2020·Turkish Journal of Biology = Türk Biyoloji Dergisi·Murat TopuzoĞullariSerap Derman
Sep 9, 2020·Cellular & Molecular Immunology·Yang LiSheng-Ce Tao
Aug 25, 2020·Advances in Cell and Gene Therapy·Wing LeungMichaela Su-Fern Seng
Sep 26, 2020·Frontiers in Medicine·Ariel D StockEmad Eskandar
Sep 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gustavo R Villas-BoasSilvia A Oesterreich
Jun 10, 2020·Science Translational Medicine·Supriya RavichandranSurender Khurana
Aug 4, 2020·Infectious Diseases of Poverty·Hong-Zhi ChenXiang Wu
Sep 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jonathan Baruch SteinmanLawrence Steinman
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Jie YuXianqun Fan
Apr 17, 2020·Vaccines·Sergio Rosales-MendozaJaime I Arévalo-Villalobos
Jun 18, 2020·Journal of Virology·Noton K DuttaJames T Gordy
Jun 24, 2020·Frontiers in Immunology·Gabriel SiracusanoLucia Lopalco
Jul 28, 2020·International Journal of Molecular Sciences·Alessandra FierabracciPaolo Rossi
Aug 4, 2020·Bulletin of the World Health Organization·Takahiko KoyamaLaxmi Parida

❮ Previous
Next ❯

Datasets Mentioned

BETA
MN908947

Software Mentioned

Sequence Variation Analysis
Discotope
NetMHCpan EL
Bepipred
YASARA
IEDB Immunobrowser
BebiPred
Tepitool
ViPR
Immunobrowser

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Related Papers

American Journal of Clinical Pathology
Ahmed BabikerJeannette Guarner
Nature Medicine
Hannah Stower
The New England Journal of Medicine
Xiaoxia LuChinese Pediatric Novel Coronavirus Study Team
© 2021 Meta ULC. All rights reserved