PMID: 2510525Nov 1, 1989Paper

A sequential study of the peripheral nervous system involvement in experimental Chagas' disease

The American Journal of Tropical Medicine and Hygiene
A LosavioR E Sica

Abstract

To search for the sequential compromise of the spinal cord, nerves, and skeletal muscle in mice chronically infected with Trypanosoma cruzi, animals were subjected to electromyographic investigation, end-plate recordings, and histological studies at 7, 15, 37, 60, 90, 120, 180, 270, and 360 days postinfection. Electromyographic studies showed signs of motor unit remodeling as early as 15 days postinfection, when diminished duration and amplitude of motor unit potentials pointing to a primary muscle involvement were found. Thereafter, certain features of denervation, reinnervation, and primary muscle involvement were often found to coexist. Low miniature end-plate potentials with normal frequency and acetylcholine quantum content were found in end-plate recordings made at the phrenic-diaphragm in vitro. Double end-plate potentials were observed in most of the tested muscle fibers from day 90 postinfection. All these features suggest post-synaptic damage of the end-plate and the presence of reinnervation after day 90 postinfection. Histological studies disclosed inflammatory infiltrates consisting of lymphocytes and macrophages, with vasculitis as the main lesion in the hamstring muscles; intracellular parasites were seen in 25% ...Continue Reading

Citations

Dec 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A FernandezG Said
Dec 1, 1991·Arquivos de neuro-psiquiatria·R E SicaM Gargia Erro
Jun 1, 1994·Arquivos de neuro-psiquiatria·C A MangoneM Segura
Jan 1, 1997·Brain Pathology·L Chimelli, F Scaravilli
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Feb 9, 2012·Cellular Microbiology·Fnu NagajyothiHerbert B Tanowitz
Mar 1, 1994·Arquivos de neuro-psiquiatria·M J SeguraR E Sica
Jan 31, 2009·Infection and Immunity·Craig Weinkauf, Mercio Pereiraperrin
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