Abstract
Since controversy exists over whether erythropoietin levels are increased or decreased after thermal injury, a prospective study was performed to answer this question as well as to characterize the erythropoietic response to thermal injury. The concept of using erythropoietin to reduce the need for blood transfusions after thermal injury is attractive. However, since the etiology of burn anemia is both unclear and multifocal, prior to initiating a trial of erythropoietin therapy, it will be necessary to better define the erythropoietic response to thermal injury. Twenty-four burn patients with a mean burn size of 31 +/- 18% had serial measurements of serum iron, total iron binding capacity (TIBC), ferritin, erythropoietin, transferrin saturation, hemoglobin, and reticulocyte counts performed on burn days 1, 3, 5, 7, 10, 14, and then weekly. The erythropoietic response was characterized by a decrease in hemoglobin levels as well as serum iron, TIBC, and transferrin saturation (p < 0.05). Ferritin and erythropoietin levels increased as did the reticulocyte count. The erythropoietin response to anemia appeared to be at least grossly intact, since there was an appropriate inverse relationship between the degree of anemia and the ma...Continue Reading
References
Mar 1, 1978·American Journal of Surgery·G F SheldonJ Schooley
Sep 1, 1991·The Journal of Burn Care & Rehabilitation·S D VaskoA S Verghese
Feb 11, 1991·Annals of Surgery·W S McDonaldE A Deitch
May 9, 1991·The New England Journal of Medicine·A J Erslev
May 24, 1990·The New England Journal of Medicine·M FischlR Zalusky
Jan 1, 1990·Transfusion·E LevineG Moss
Jun 1, 1990·Annals of Surgery·M H DesaiR L Rutan
Feb 1, 1989·Kidney International·D B Van WyckD A Ogden
Jul 1, 1989·The Journal of Trauma·T A GravesB A Pruitt
Jan 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·S F Wallner, R Vautrin
Jan 1, 1987·Cancer Metastasis Reviews·E D Letendre
Feb 6, 1985·Nature·K JacobsE F Fritsch
Oct 1, 1985·Burns, Including Thermal Injury·S F Wallner, G H Warren
Mar 1, 1972·American Heart Journal·M A VaratN O Fowler
Feb 1, 1974·The Journal of Surgical Research·E C LoeblC R Baxter
Sep 1, 1971·Canadian Journal of Surgery. Journal Canadien De Chirurgie·D C Birdsell, J R Birch
Oct 10, 1968·The New England Journal of Medicine·J W Linman
Apr 1, 1984·Burns, Including Thermal Injury·S WallnerV Peterson
Sep 1, 1982·The Journal of Trauma·S F WallnerV M Peterson
Citations
Aug 28, 2001·Lipids·V C PrattC J Field
Aug 16, 2001·Annals of Surgery·J C WuP Rameshwar
Sep 6, 2001·The Journal of Trauma·K Prelack, R L Sheridan
Nov 9, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Peter KwanRobert Cartotto
Oct 28, 2003·Annals of Surgery·David H LivingstonPranela Rameshwar
Jul 11, 2009·The Journal of Trauma·Marie-Louise OttermanMaarten W N Nijsten
Sep 8, 2001·Critical Care Medicine·D J AnjariaD H Livingston
Jun 3, 2008·Burns : Journal of the International Society for Burn Injuries·Mitra BaratiHamid Karimi
Jul 1, 2004·Burns : Journal of the International Society for Burn Injuries·Patricia Muller, Daniel Lozano
May 14, 2016·Shock·Tyler J LoftusAlicia M Mohr
Jan 19, 2017·The Journal of Trauma and Acute Care Surgery·Ines G AlamoAlicia M Mohr
Jan 8, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·K N WilliamsK Muthumalaiappan
Dec 30, 2016·American Journal of Physiology. Cell Physiology·Shirin HasanKuzhali Muthumalaiappan
Feb 26, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Joseph A Posluszny, Richard L Gamelli
Jul 8, 2020·Methods and Protocols·Julia WalczakKuzhali Muthumalaiappan
Jan 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason C GardnerFrancis X McCormack
Aug 26, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Julia WalczakKuzhali Muthumalaiappan
Jul 12, 2016·The Journal of Trauma and Acute Care Surgery·Ines G AlamoAlicia M Mohr
Dec 12, 2019·Frontiers in Medicine·Shirin HasanKuzhali Muthumalaiappan
Aug 26, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul B ComishDaolin Tang