A series of malignant ovarian cancers arising from within a mature cystic teratoma: a single institution experience

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Jonathan D BlackElena Ratner

Abstract

Mature cystic teratoma (MCT) is the most common germ cell tumor. It accounts for 10% to 20% of all ovarian masses. The likelihood of malignancy arising from within an MCT is low, and prognosis is poor. A single-institution retrospective chart review was completed of all cases of MCT from 2004 to 2012. Multiple variables were examined including procedure performed, residual disease after surgery, surgical stage, histologic type, site of primary disease, date of recurrence, whether or not adjuvant chemotherapy was given, and whether or not there was death secondary to disease. During the study period, 1.2% of MCTs exhibited malignant transformation. The average age at presentation was 53.7 years. Mean follow-up time was 23 months. The most common presenting symptoms were bloating and abdominal pain. The average tumor size was 18 cm. Of note, 33% of cases were at least surgical stage IIIC at the time of presentation, whereas the remainder were stage IC or lower. Four (44.4%) of the 9 cases were identified as mucinous adenocarcinoma in addition to 1 case each of malignant melanoma, squamous cell carcinoma, and poorly differentiated adenocarcinoma. Only 1 patient experienced recurrence. One patient had a known MCT that was being man...Continue Reading

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Citations

Feb 19, 2017·Pathology, Research and Practice·Levent TrabzonluAydin Corakci
Oct 26, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Munetoshi Akazawa, Sachiko Onjo
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Jun 27, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicola S MeagherMartin Köbel

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