PMID: 2123555Dec 1, 1990Paper

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism

Proceedings of the National Academy of Sciences of the United States of America
J D MorrowL J Roberts

Abstract

Increasing attention has focused on the role of free radicals derived from oxygen in the pathophysiology of a wide variety of disorders. One of the well-recognized targets of free radical-induced injury is peroxidation of lipids. Using a variety of approaches, we have found that a series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase mechanism involving free radical-catalyzed peroxidation of arachidonic acid. Levels of these compounds in normal human plasma and urine range from 5 to 40 pg/ml and 500 to 4000 pg/mg of creatinine, respectively. In rats, their formation was found to increase as much as 200-fold in association with marked free radical-catalyzed lipid peroxidation induced by administration of CCl4 and diquat. To explore whether these prostanoids can exert biological activity, the effects of one of the compounds formed by this mechanism, 8-epi-prostaglandin F2 alpha, was examined in the kidney in the rat. Infusion of 8-epi-prostaglandin F2 alpha into a peripheral vein (5 micrograms/kg per min) or intrarenally (0.5-2.0 micrograms/kg per min) resulted in marked parallel reductions in renal blood flow and glomerular filtration rate. That the formation of these prostanoids is cat...Continue Reading

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Citations

May 16, 2001·Arthritis and Rheumatism·J L CracowskiG Bessard
Sep 5, 2002·Annals of Neurology·Thomas J MontineJason D Morrow
Sep 28, 1998·Annals of Neurology·T J MontineL J Roberts
Jul 1, 1996·Arthritis and Rheumatism·C M SteinJ D Morrow
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B FernandoK Moore
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·Hsiu-Chuan YenLai-Chu See
Dec 10, 1998·Journal of Biomedical Science·T Z LiuJ D Morrow
May 29, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Savino SciasciaSimone Baldovino
Jun 2, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Federico Manuel DarayRodolfo Pedro Rothlin
Mar 25, 2010·Pflügers Archiv : European journal of physiology·Michel FélétouPaul M Vanhoutte
Feb 6, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Qinghao ChengYun Yue
Nov 9, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W ŁuczajE Skrzydlewska
Sep 18, 2012·Molecular and Cellular Biochemistry·Magdalena BrysBeata Olas
Jun 8, 2007·Journal of Thrombosis and Thrombolysis·Andrew D AtiemoMarlene S Williams
Oct 10, 2006·Sleep & Breathing = Schlaf & Atmung·Hawley E Montgomery-DownsDavid Gozal
Feb 7, 2007·Sleep & Breathing = Schlaf & Atmung·Mónica de la Peña BravoDavid Gozal
Jun 21, 2007·Sleep & Breathing = Schlaf & Atmung·Athanasios G KaditisGeorge A Syrogiannopoulos
Sep 29, 2007·Journal of Molecular Neuroscience : MN·Erik S MusiekJason D Morrow
Sep 29, 2007·Journal of Molecular Neuroscience : MN·Thomas J MontineJason D Morrow
Jul 8, 2010·Genes & Nutrition·Mario ComportiBeatrice Arezzini
Mar 9, 2012·Genes & Nutrition·Claudio De FeliceJoussef Hayek
Nov 11, 1992·Biochimica Et Biophysica Acta·M Hamberg, H W Gardner
Jan 3, 1994·Biochimica Et Biophysica Acta·J D MorrowL J Roberts
Jun 11, 1996·Biochimica Et Biophysica Acta·D M StafforiniT M McIntyre
May 1, 1995·General Pharmacology·R A Armstrong, N H Wilson
Sep 15, 1995·Journal of Chromatography. B, Biomedical Applications·A Kuksis, J J Myher
Jan 1, 1991·Free Radical Biology & Medicine·J D Morrow, L J Roberts
Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Jan 1, 1996·Free Radical Biology & Medicine·O I Aruoma
Dec 1, 1995·Free Radical Biology & Medicine·J AwadL J Roberts

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