A serologic study of dengue in northwest Ethiopia: Suggesting preventive and control measures

PLoS Neglected Tropical Diseases
Getachew FeredeBelay Tessema

Abstract

Dengue is one of the most serious and rapidly spreading arboviral diseases in the world. Despite many acute febrile illnesses in Ethiopia, the burden of illness due to dengue in the country is largely unknown. Thus, the present study aimed to provide the first baseline data on seroprevalence and associated risk factors of dengue virus (DENV) infection in the country. A cross-sectional study of febrile patients who were visiting Metema and Humera hospitals in Northwest Ethiopia from March 2016 to May 2017 was conducted. Blood samples were collected from each participant and serum samples were separated and tested for IgM and IgG antibodies against DENV infection by enzyme-linked immunosorbent assay (ELISA). Risk factors associated with the prevalence of anti-DENV antibodies were tested using logistic regression analysis. Of the 600 samples tested, the overall seroprevalence against DENV infection was 33.3%, while the seroprevalence by the study area was 40% in Metema and 27.5% in Humera. The overall prevalence of IgM and IgG antibodies against DENV infection was 19% and 21% respectively. Of these, 6.7% were positive for both IgM and IgG antibodies. Residence and occupational status were significantly associated with the prevalen...Continue Reading

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Citations

Dec 10, 2020·PLoS Neglected Tropical Diseases·Arwa ElaagipMuzamil Mahdi Abdel Hamid
Jan 20, 2021·PLoS Neglected Tropical Diseases·Mulugeta Asefa GutuDavid Sugerman
Nov 9, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Simon PollettJ N Waitumbi
Jan 15, 2022·Tropical Medicine & International Health : TM & IH·Yibeltal AkelewLieselotte Cnops
Jan 25, 2022·PLoS Neglected Tropical Diseases·Martin WainainaSascha Al Dahouk

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Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

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