Abstract
DNA-metal nanoparticle conjugates have been increasingly exploited for sensing purposes over the past decades. However, most of the existing strategies are operated with canonical DNA structures, such as single-stranded forms, stem-loop structures, and double helix structures. There is intense interest in the development of nano-system based on high order DNA secondary structures. Herein, we propose a SERS/fluorescence dual-mode nanosensor, where the signal transduction mechanism is based on the conformational switching of the human telomeric G-quadruplex DNA. The nanosensor exhibits excellent SERS/fluorescence responses to the complementary strands of G-quadruplexes. Based on T-Hg(2+)-T coordination chemistry, this sensor is effectively applied to determination of Hg(2+) in buffer solution and real samples. It achieves a limit of detection (LOD) as low as 1ppt, which is ~100 times more sensitive than conventional optical sensors. We anticipate that the proposed G-quadruplex-based nanosensor could be applied to the analysis of other metal ions and small molecules in environmental samples and biological systems.
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Citations
Feb 24, 2016·Journal of Environmental Sciences (China)·Zhenli SunChuanyong Jing
Sep 12, 2015·Biosensors & Bioelectronics·Lanying LiGang Liu
May 24, 2017·Chemical Reviews·Zhuyuan WangYiping Cui
Apr 4, 2018·Small·Yiman LiuMin Liu
Nov 6, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Bin ZhouQing-Li Suo
May 14, 2016·Scientific Reports·Xiangmin MiaoDik-Lung Ma
Nov 30, 2019·Small·Min LiuYiman Liu
Feb 1, 2017·Nanotechnology·Zhile WangYiping Cui
Mar 3, 2021·Analytical Chemistry·Zhaoping XiaWei Deng
Mar 30, 2017·Analytica Chimica Acta·Tao WuYong Shao
Apr 2, 2021·Frontiers in Chemistry·Chongning LiZhiliang Jiang
Apr 4, 2021·Biomolecules·Shuchang Wang
Apr 23, 2021·Biosensors & Bioelectronics·Yuwei TianWeizhi Wang
Jun 14, 2021·Biosensors & Bioelectronics·Yaofeng ZhouYonghua Xiong
Nov 19, 2015·ACS Applied Materials & Interfaces·Min LiuYiman Liu