PMID: 12778383Jun 5, 2003Paper

A serum factor(s) after small bowel resection induces intestinal epithelial cell proliferation: effects of timing, site, and extent of resection

Journal of Pediatric Surgery
Russell J JunoB W Warner

Abstract

After small bowel resection (SBR), serum induces proliferation in rat intestinal epithelial cells (RIEC-6). This study was designed to elucidate the effects of postoperative time interval, site, and magnitude of SBR on RIEC-6 proliferation. Serum was collected from rats at various times after a 75% mid-SBR or sham operation and added to RIEC-6 cells and growth determined over 5 days. In other experiments, cell growth was recorded in the presence of serum from rats after 25%, 50%, or 75% SBR, or after jejunal or ileal SBR. SBR serum enhanced RIEC-6 cell proliferation as early as 12 hours after resection. The extent of SBR directly correlated with the level of adaptation; however, the effects on cell growth by the serum were similar. SBR serum induced proliferation equally after either proximal or distal resection. Serum contains a factor that stimulates intestinal cell proliferation soon after SBR but independent of the degree or site of intestinal resection. Although humoral factor(s) play a role in the early induction of enterocyte proliferation after SBR, further modulation of adaptation to varied lengths or sites of intestinal resection are probably governed by mechanisms independent of factors that circulate in the serum.

References

Jun 29, 1978·The New England Journal of Medicine·R C Williamson
Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·R H Dowling
Aug 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·A I SacksJ A Barnard
Nov 1, 1996·Journal of the American College of Surgeons·M A HelmrathB W Warner
Apr 20, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·D R CronkJ S Thompson
Oct 31, 2000·Microscopy Research and Technique·L E SternB W Warner
Apr 4, 2001·JPEN. Journal of Parenteral and Enteral Nutrition·E E Whang, K R Shen
May 1, 2001·Seminars in Pediatric Surgery·D P O'BrienB W Warner

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Citations

Nov 25, 2005·Pediatric Surgery International·Emir Q HaxhijaDaniel H Teitelbaum
Jan 6, 2007·Pediatric Surgery International·Emir Q HaxhijaDaniel H Teitelbaum
May 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Emir Q HaxhijaDaniel H Teitelbaum
Jul 14, 2010·Journal of Pediatric Surgery·Derek WakemanBrad W Warner
Mar 4, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Kelly A Tappenden
Oct 20, 2014·Nature Medicine·Carey L WatsonMichael A Helmrath

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