A serum haemagglutinating property dependent upon polycarboxyl groups

British Journal of Haematology
M L BeckW L Bayer

Abstract

A serum agglutinin reactive with red cells in the presence of polycarboxyl groups is reported. It is likely that this represents an additional example of the type of agglutinin previously described as agglutinating red cells in the absence of ionized calcium. Experimental evidence is presented indicating that it is free polycarboxyl groups that potentiate agglutination and that any metal ion, such as calcium, capable of chelating with these groups will prove to be inhibitory.

References

May 1, 1973·Transfusion·J K HysellJ M Gray
Jan 1, 1972·Vox Sanguinis·T D GillundB Isham
Dec 1, 1969·Vox Sanguinis·H H Gunson
Mar 1, 1968·Transfusion·M L Beck
Nov 22, 2005·Journal of the Air & Waste Management Association·Alan R LestonJan Satola
Jul 5, 2007·Journal of Lipid Research·Barbara P AtshavesFriedhelm Schroeder
Aug 1, 1949·Postgraduate Medical Journal·T J D LANE

Citations

Jun 6, 2009·Veterinary Clinical Pathology·Deanna M W SchaeferNicole Belcher
Jun 1, 2013·Journal of Clinical Pathology·Jose Manuel VagaceGuillermo Gervasini
May 9, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe BanfiGiuseppe Lippi
Oct 1, 1980·Vox Sanguinis·T LewisD R Avoy
Jan 10, 2018·Journal of General Internal Medicine·Aisha JamesSteven J Atlas

Related Concepts

Blood Group H Type 1 Antigen
Agglutinins
Antibody Specificity
Carboxylic Acids
Cations, Divalent
Citrates
Edetic Acid, Calcium, Sodium Salt
Ficain
Hemagglutination
Hydrogen-Ion Concentration

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.