A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts

American Journal of Respiratory and Critical Care Medicine
Jeannette BiglerU-BIOPRED Study Group ‖

Abstract

Stratification of asthma at the molecular level, especially using accessible biospecimens, could greatly enable patient selection for targeted therapy. To determine the value of blood analysis to identify transcriptional differences between clinically defined asthma and nonasthma groups, identify potential patient subgroups based on gene expression, and explore biological pathways associated with identified differences. Transcriptomic profiles were generated by microarray analysis of blood from 610 patients with asthma and control participants in the U-BIOPRED (Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes) study. Differentially expressed genes (DEGs) were identified by analysis of variance, including covariates for RNA quality, sex, and clinical site, and Ingenuity Pathway Analysis was applied. Patient subgroups based on DEGs were created by hierarchical clustering and topological data analysis. A total of 1,693 genes were differentially expressed between patients with severe asthma and participants without asthma. The differences from participants without asthma in the nonsmoking severe asthma and mild/moderate asthma subgroups were significantly related (r = 0.76), with a larger effect size in the severe ...Continue Reading

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References

Apr 20, 2001·The European Respiratory Journal·H DerendorfJ Efthimiou
Oct 9, 2002·The Biochemical Journal·Martin GriffinCarlo M Bergamini
Feb 18, 2005·Respiratory Medicine·Lan Tien NguyenKian Fan Chung
Dec 22, 2005·Bioinformatics·Alexander PlonerYudi Pawitan
Apr 15, 2006·American Journal of Respiratory and Critical Care Medicine·Mark HewKian Fan Chung
Jan 26, 2007·BMC Bioinformatics·Andy M Yip, Steve Horvath
Sep 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Prescott G WoodruffJohn V Fahy
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Jun 2, 2009·American Journal of Respiratory and Critical Care Medicine·Prescott G WoodruffJohn V Fahy
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas Pabst, Beatrice U Mueller
Nov 26, 2010·Thorax·Elisabeth H BelUNKNOWN Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome (U-BIOPRED) Consortium, Consensus Generation
May 3, 2011·Current Opinion in Pharmacology·Tiina JääskeläinenJorma J Palvimo
Jan 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Wenzel
Feb 14, 2012·Autoimmunity Reviews·Antonio Di SabatinoGino Roberto Corazza
Nov 21, 2012·British Journal of Clinical Pharmacology·Stephen T Holgate
Dec 4, 2012·American Journal of Respiratory and Critical Care Medicine·Fernando HolguinSally E Wenzel
Feb 9, 2013·Scientific Reports·P Y LumG Carlsson
Feb 12, 2013·The European Respiratory Journal·Craig E WheelockUNKNOWN U-BIOPRED Study Group
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes
May 22, 2013·The New England Journal of Medicine·Sally WenzelGianluca Pirozzi
Oct 30, 2013·Expert Review of Respiratory Medicine·John T Lindsay, Liam G Heaney
Dec 1, 2013·Annals of the American Thoracic Society·Kian Fan Chung, Ian M Adcock
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Dec 18, 2013·The European Respiratory Journal·Kian Fan ChungW Gerald Teague
Sep 10, 2014·The New England Journal of Medicine·Hector G OrtegaUNKNOWN MENSA Investigators
Dec 10, 2014·The Journal of Allergy and Clinical Immunology·Douglas C CowanSuzy A A Comhair
Feb 11, 2015·The Journal of Allergy and Clinical Immunology·Merritt L Fajt, Sally E Wenzel
Mar 10, 2015·The Journal of Allergy and Clinical Immunology·Timothy S C HinksRatko Djukanović
Sep 12, 2015·The European Respiratory Journal·Dominick E ShawUNKNOWN U-BIOPRED Study Group
Oct 16, 2015·Nature Communications·Jessica L NielsonAdam R Ferguson
Oct 30, 2015·Science Translational Medicine·Li LiJoel T Dudley
May 9, 2016·The Journal of Allergy and Clinical Immunology·Alalia Berry, William W Busse

❮ Previous
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Citations

Mar 31, 2018·Current Opinion in Allergy and Clinical Immunology·Fulvio BraidoIpek Kivilcim Oguzulgen
Feb 22, 2018·American Journal of Respiratory and Critical Care Medicine·Lawrence E K Gray, Peter D Sly
May 15, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-L YehY L Lee
Sep 1, 2018·Annual Review of Genomics and Human Genetics·Saffron A G Willis-OwenMiriam F Moffatt
Sep 1, 2018·European Journal of Immunology·Marc KästleDavid Wyatt
Aug 15, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Yamini V VirkudJessica A Lasky-Su
Oct 6, 2018·Allergy·Ibon Eguiluz-GraciaMaria J Torres
Jan 15, 2019·Pharmacogenetics and Genomics·Alberta L WangKelan G Tantisira
Mar 17, 2018·ERJ Open Research·Cecilia AnderssonAlexander G Mathioudakis
Oct 21, 2017·The European Respiratory Journal·Inke R KönigMatthias V Kopp
Apr 4, 2019·Frontiers in Pediatrics·Andrew Bush
May 17, 2019·Human Molecular Genetics·Yadu GautamTesfaye B Mersha
Jun 5, 2019·American Journal of Respiratory and Critical Care Medicine·Nathaniel WeathingtonBrian D Modena
Aug 5, 2017·Respiratory Research·Mengyuan KanBlanca E Himes
Jun 6, 2019·American Journal of Respiratory and Critical Care Medicine·Ratko Djukanović
Nov 29, 2017·American Journal of Respiratory and Critical Care Medicine·Ratko Djukanović
Jan 24, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sandra Hodge
Jan 26, 2020·International Journal of Molecular Sciences·Lei FangMichael Roth
Mar 7, 2020·Allergy, Asthma & Immunology Research·Heung Woo Park, Scott T Weiss
Feb 26, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Elizabeth R DaviesUNKNOWN U-BIOPRED Study Group
Aug 15, 2020·Journal of Leukocyte Biology·Cesar Augusto Prada-MedinaHelder I Nakaya
Jul 12, 2018·BioMed Research International·Carla GaleoneFrancesco Menzella
Oct 18, 2019·The European Respiratory Journal·Howard H F TangMichael Inouye
Jun 23, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Chen Xingyuan, Qiu Chen
Sep 17, 2020·International Journal of Environmental Research and Public Health·Joan ReibmanYongzhao Shao
Feb 2, 2018·American Journal of Respiratory Cell and Molecular Biology·Emma de Jong, Anthony Bosco
Feb 2, 2018·Current Opinion in Allergy and Clinical Immunology·Levi B RichardsAnke H Maitland-van der Zee
Mar 24, 2018·American Journal of Respiratory and Critical Care Medicine·Damien C Croteau-Chonka, Benjamin A Raby
Sep 4, 2018·Pharmaceutical Medicine·Jean-Emmanuel FaureLine Matthiessen
Feb 26, 2019·Frontiers in Pediatrics·Natalia Hernandez-PachecoCarlos Flores
Jan 30, 2019·American Journal of Respiratory Cell and Molecular Biology·Mengyuan KanBlanca E Himes
Sep 13, 2018·Healthcare·Theis Skovsgaard ItenovJens Ulrik Stæhr Jensen
Nov 28, 2018·Allergy, Asthma & Immunology Research·Byung Keun KimHeung Woo Park
May 31, 2018·BMC Systems Biology·Bertrand De MeulderUNKNOWN U-BIOPRED Study Group and the eTRIKS Consortium
Sep 13, 2018·Clinical Reviews in Allergy & Immunology·Merin E KuruvillaGerald B Lee
Oct 12, 2017·Frontiers in Medicine·Sarah Svenningsen, Parameswaran Nair
Sep 14, 2018·Journal of Healthcare Engineering·Wenchao TangKe Ning
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Joost BrandsmaUNKNOWN U-BIOPRED Study Group
Mar 14, 2019·Journal of Integrative Bioinformatics·Alban ShoshiElena Yu Bragina
Dec 14, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Daniel HeScott J Tebbutt

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