A sex difference in the cortisol response to tail docking and ACTH develops between 1 and 8 weeks of age in lambs

The Journal of Endocrinology
A I TurnerA J Tilbrook

Abstract

It is important to understand factors that may influence responses to stress, as these factors may also influence vulnerability to pathologies that can develop when stress responses are excessive or prolonged. It is clear that, in adults, the sex of an individual can influence the cortisol response to stress in a stressor specific manner. Nevertheless, the stage of development at which these sex differences emerge is unknown. We tested the hypothesis that there are sex differences in the cortisol response to tail docking and ACTH in lambs of 1 and 8 weeks of age. We also established cortisol responses in males when tail docking was imposed alone and in combination with castration at these ages. In experiment 1, 1 and 8 week old male and female lambs were subjected to sham handling, tail docking or, in males, a combination of tail docking and castration. In experiment 2, we administered ACTH (1.0 IU/kg) to male and female lambs at 1 and 8 weeks of age. There were significant cortisol responses to all treatments at both ages. Sex differences in the cortisol responses to tail docking and ACTH developed between 1 and 8 weeks of age, with females having greater responses than males. The data suggest that the mechanism for the sex di...Continue Reading

Citations

Apr 27, 2010·The British Journal of Nutrition·Susan J TorresCaryl A Nowson
Apr 29, 2018·The Journal of Endocrinology·John-Paul Fuller-Jackson, Belinda A Henry
Nov 4, 2010·Pediatric Research·Dino A GiussaniDavid S Gardner
Jan 22, 2020·The Veterinary Record·Madeleine Eloise WoodruffCarolina Munoz
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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