PMID: 9535157Apr 16, 1998Paper

A sex-linked Ace gene, not linked to insensitive acetylcholinesterase-mediated insecticide resistance in Culex pipiens

Insect Molecular Biology
C A MalcolmM Raymond

Abstract

An acetylcholinesterase (AChE) gene, Ace.x, showing 93% identity of deduced amino acid sequence to Anopheles stephensi Ace has been cloned from a Culex pipiens strain homozygous for insensitive AChE (iAChE) mediated insecticide resistance. DNA sequence of genomic DNA clones identified exons 2-5. RFLP of six clones indicated four possible alleles. Linkage analysis located Ace.x to chromosome I, less than 0.8 centimorgans from the sex locus, whereas the locus conferring resistance was 2.0 centimorgans from plum-eye on chromosome II. Ace.1 coding for AChE1, which is associated with resistance, is therefore autosomal. We propose that Ace.x is the recently postulated Ace.2 coding for the biochemically distinct AChE2, which is not associated with resistance.

Citations

Jan 5, 2000·International Journal for Parasitology·G D Baxter, S C Barker
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Mar 12, 2002·Insect Biochemistry and Molecular Biology·A TsagkarakouM Navajas
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Jun 25, 2002·Proceedings. Biological Sciences·Claire BerticatMylène Weill
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Apr 11, 2006·Genome Génome / Conseil National De Recherches Canada·Maohua Chen, Zhaojun Han

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