A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster

The Journal of Endocrinology
Marcello CanonacoMarcello Maggiolini

Abstract

The isolation of the G-protein-coupled receptor 30 (GPR30), an orphan membrane receptor unrelated to nuclear estrogen receptors (ERs), has become a key factor towards the unraveling of rapid estrogen action. This membrane receptor together with cellular signaling intermediaries, i.e., extracellular signal-dependent kinases 1 and 2, may promote neuronal proliferation and differentiation activities. In the present study, an evident gene expression pattern of GPR30 characterized postnatal 7 (young) and 60 (adult) days of age hamsters as shown by its heterogeneous mRNA distribution in hypothalamic, amygdalar and cerebellar areas of both sexes. In particular, most of the brain areas considered in the adult hamster plus only the amygdala and cerebellum of young animals behaved in a sexually dimorphic fashion. This similar pattern was also detected for the ERalpha and beta, as shown by the latter receptor prevailing in young and adult females, while the former predominated in young females. Even for the two kinases, a sexually dimorphic distribution was featured above all for young hamsters. Overall, the findings of the present study established a distinct expression pattern of the novel ER (GPR30) that may operate differently in some...Continue Reading

Citations

Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Xuan YuGuichun Han
Oct 30, 2012·Experimental Physiology·G Cristina BrailoiuEugen Brailoiu
Apr 3, 2013·Molecular and Cellular Endocrinology·Isabel Ruiz-PalmeroMaria-Angeles Arevalo
Nov 17, 2009·Brain Research·Keiko TakanamiMitsuhiro Kawata
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Mar 3, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Lei ChenXu-De Sun
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Apr 17, 2020·Frontiers in Endocrinology·Jing Luo, Dongmin Liu
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