PMID: 15240701Jul 9, 2004Paper

A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yuko KimuraT Seya

Abstract

The prototype of the short consensus repeat (SCR)-containing C regulatory protein is of interest in view of its evolutionary significance with regard to the origin of the C regulatory system. Lamprey is an agnathan fish that belongs to the lowest class of vertebrates. Because it does not possess lymphocytes, it lacks Ig and consequently the classical C pathway. We identified an SCR-containing C regulatory protein from the lamprey. The primary structure predicted from the cDNA sequence showed that this is a secretary protein consisting of eight SCRs. This framework is similar to the alpha-chain of C4b-binding protein (C4bp). SCR2 and -3 of human C4bp are essential for C4b inactivation, and this region is fairly well conserved in the lamprey protein. However, the other SCRs of this protein are similar to those of other human C regulatory proteins. The lamprey protein binds to the previously reported lamprey C3b/C3bi deposited on yeast and cleaves lamprey C3b-like C3 together with a putative serum protease. The scheme resembles the C regulatory system of mammals, where factor I and its cofactor inactivate C3b. Unlike human cofactors, the lamprey protein requires divalent cations for C3b-like C3 cleavage. Its artificial membrane-an...Continue Reading

References

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Citations

Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Momoe TakahashiTeizo Fujita
Jan 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fenfang WuQingwei Li
Dec 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masakazu TsujikuraMiki Nakao
Aug 10, 2006·Immunogenetics·Masaru Nonaka, Ayuko Kimura
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akihiro IshiiTsukasa Seya
Mar 26, 2009·Immunogenetics·Hiroyuki OshiumiTsukasa Seya
Apr 25, 2013·PloS One·Lucy V HolmesTimothy H J Goodship
Jul 4, 2018·Frontiers in Immunology·Misao Matsushita
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroyuki OshiumiTsukasa Seya
Jul 30, 2010·Functional & Integrative Genomics·Guanni SunShicui Zhang
May 16, 2006·Immunobiology·Yuichi EndoTeizo Fujita

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