A short report on current fertility preservation strategies for boys

Clinical Endocrinology
Wei Li Cindy HoPaediatric & Adolescent Fertility Preservation Task Force, Melbourne

Abstract

Advances in cancer treatment have led to improved long-term survival after childhood cancer, but often at a price of impaired future fertility. Fertility preservation (FP) in male children and early adolescents poses unique challenges as efficacy is unproven. To describe characteristics of testicular tissue cryopreservation (TTCP) specimens taken from paediatric and adolescent patients, stratified by age, and prior chemotherapy, if any, and to demonstrate evidence for germ cells. Retrospective review of gonadal biopsies and clinical records of patients consented into the Royal Children's Hospital FP programme between 1987 and 2015. Tissue was sliced into blocks, with one section sent for histopathology prior to cryopreservation. In boys ≥12 years where spermatogenesis could be expected, a portion of tissue was disaggregated completely to look for mature sperm and if found, additional tissue was dissected and the resulting suspension frozen. Testicular tissue cryopreservation specimens in 44 males (0.3-16.8 years) provided an average of 7.8 slices per patient. All the specimens were taken at the same time as another necessary surgical procedure, under one general anaesthesic. There was only one complication of scrotal wound dehi...Continue Reading

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Citations

Jun 4, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Y WangA Anazodo
Dec 5, 2019·Clinical Medicine Insights. Reproductive Health·Aude BrayeEllen Goossens
Jun 23, 2020·European Journal of Cancer Care·Elisabeth KorteAnja Borgmann-Staudt
Jul 5, 2018·Pediatric Blood & Cancer·Antoinette AnazodoTeresa K Woodruff
Jun 13, 2020·Human Reproduction Open·E GoossensJ B Stukenborg
Jan 17, 2021·Journal of Assisted Reproduction and Genetics·UNKNOWN Practice Committee of the Oncofertility Consortium

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