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A short, stereocontrolled, and practical synthesis of alpha-methylomuralide, a potent inhibitor of proteasome function

The Journal of Organic Chemistry

Mar 29, 2003

P Saravanan, E J Corey

Abstract

An efficient and practical synthesis of alpha-methylomuralide (3), a selective inhibitor of proteasomes, has been developed as outlined in Scheme 1. Among the advantages of this route of synthesis over previously described approaches are (1) ease of scale-up and (2) high yields (28% ove...read more

Mentioned in this Paper

Molecular Stereochemistry
Proteasome Pathway
Combinatorial Chemistry Techniques
Lactones
alpha-methylomuralide
Proteasome Complex Location (Sensu Eukarya)
Catalysis
Proteasome Activity
Multicatalytic endopeptidase complex
Lactims
16
Paper Details
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A short, stereocontrolled, and practical synthesis of alpha-methylomuralide, a potent inhibitor of proteasome function

The Journal of Organic Chemistry

Mar 29, 2003

P Saravanan, E J Corey

PMID: 12662049

DOI: 10.1021/jo0268916

Abstract

An efficient and practical synthesis of alpha-methylomuralide (3), a selective inhibitor of proteasomes, has been developed as outlined in Scheme 1. Among the advantages of this route of synthesis over previously described approaches are (1) ease of scale-up and (2) high yields (28% ove...read more

Mentioned in this Paper

Molecular Stereochemistry
Proteasome Pathway
Combinatorial Chemistry Techniques
Lactones
alpha-methylomuralide
Proteasome Complex Location (Sensu Eukarya)
Catalysis
Proteasome Activity
Multicatalytic endopeptidase complex
Lactims
16

Trending Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Bioorganic & Medicinal Chemistry Letters

N-Aryl-gamma-lactams as integrin alphavbeta3 antagonists

Bioorganic & Medicinal Chemistry LettersMay 6, 2004
Ning XiCelia Dominguez
Paper Details
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  • Citations15
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