A short-term scan-rescan reliability test measuring brain tissue and subcortical hyperintensity volumetrics obtained using the lesion explorer structural MRI processing pipeline.

Brain Topography
Joel RamirezSandra E Black

Abstract

Lesion Explorer (LE) is a reliable and comprehensive MRI-derived tissue segmentation and brain region parcellation processing pipeline for obtaining intracranial tissue and subcortical hyperintensity (SH) volumetrics. The processing pipeline segments: gray (GM) and white matter (WM); sulcal (sCSF) and ventricular cerebrospinal fluid (vCSF); periventricular (pvSH) and deep white subcortical hyperintensities (dwSH); and cystic fluid filled lacunar-like infarcts (Lacunar); into 26 regions of interest. A short-term scan-rescan reliability test was performed on 20 healthy volunteers: 10 older (mean = 77.7 years, SD = 11.1) and 10 younger (mean = 29.4 years, SD = 7.1). Each participant was scanned twice with an average interscan interval of 15.4 days (range: 29 min-50 days). Results suggest low technique-related error as indicated by excellent intraclass correlation coefficient (ICC) results, with ICCs above 0.90 (p < 0.05) for GM, WM, and CSF, in all 26 regions of interest (13 per hemisphere). Ventricular and lesion sub-type (pvSH, dwSH, and Lacunar) volumes also showed high scan-rescan reliability (dwSH = 0.9998, pvSH = 0.9998, Lacunar = 0.9859, p < 0.01). As indicated by the results of this short-term scan-rescan study, the LE str...Continue Reading

References

Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerUNKNOWN Rotterdam Scan Study
Jan 17, 2004·Stroke; a Journal of Cerebral Circulation·António J Bastos LeiteFrederik Barkhof
Nov 10, 2004·Neurology·D M J van den HeuvelUNKNOWN PROSPER Study Group
Oct 22, 2005·Stroke; a Journal of Cerebral Circulation·Perminder Sachdev, Wei Wen
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·D M J van den HeuvelM A van Buchem
Aug 19, 2006·Stroke; a Journal of Cerebral Circulation·Vladimir HachinskiGabrielle G Leblanc
Jan 17, 2007·Neurology·Perminder SachdevHenry Brodaty
Oct 18, 2008·Stroke; a Journal of Cerebral Circulation·Velandai SrikanthDavid Reutens
Dec 27, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroshi KogaHiroshi Yao

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Citations

Feb 25, 2014·Neuropsychologia·Fergus I M CraikSandra E Black
May 14, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·François De GuioHugues Chabriat
Aug 28, 2020·Frontiers in Neurology·Joel RamirezUNKNOWN ONDRI Investigators
May 16, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Sanjana ShellikeriYana Yunusova
Dec 22, 2020·Journal of Magnetic Resonance Imaging : JMRI·Luca MelazziniMarina Codari
Aug 28, 2018·Psychiatry Research. Neuroimaging·Keith S CoverUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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