A short-term study of the effects of SBHAN, a novel compound, on gingival inflammation in the beagle dog

Journal of Periodontology
C W Cutler, K A Ghaffar

Abstract

Unique hydroxyl ion-modulating compounds based on the amino acid glycine have been developed that possess both antimicrobial and pro-healing properties. The purpose of the present study was to determine the effects of one of these compounds, 8.5% (w/v) sodium N, N-bis-2 (hydroxylethyl) aminoacetate (SBHA) with 0.3% (w/v) NaOH (SBHAN) on ligature-induced gingival inflammation in the beagle dog. Fifteen purebred beagle dogs were subjected to a 14-day oral hygiene regimen, consisting of manual scaling and daily toothbrushing with plain pumice. Gingival inflammation was then initiated by tying ligatures around 12 study teeth per dog and by placing the dogs on water-softened dog chow. After 30 days, ligatures were removed, dogs were placed on a hard diet and randomly assigned to five treatment groups by the flip of two coins. The five treatments included: 1) distilled, pyrogen-free water; 2) 8.5% (w/v) SBHAN; 3) 4.3% (w/v) SBHAN; 4) 0.12% chlorhexidine; and 5) 8.5% SBHA (w/v) (SBHAN without added NaOH). Solutions were placed in opaque spray bottles to shield their identity from the examiner. Treatment consisted of a daily aerosol application of 2 ml of each solution in a calibrated spray bottle to the affected teeth. The following m...Continue Reading

References

Oct 1, 1992·Journal of Clinical Periodontology·B KlingeS Edwardsson
May 1, 1988·Journal of Periodontal Research·R C WilliamsP Goldhaber
Dec 16, 1987·Biochemical and Biophysical Research Communications·M P HeatonT L Thompson
Mar 1, 1980·Journal of Periodontal Research·S A SyedG Svanberg
Nov 1, 1981·Journal of Periodontology·K Tsuchida, K Hara
Aug 1, 1994·Journal of Clinical Periodontology·M GiargiaA M Neiderud
Dec 1, 1963·Acta Odontologica Scandinavica·H LOE, J SILNESS

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