A signature of 17 immune-related gene pairs predicts prognosis and immune status in HNSCC patients

Translational Oncology
Pan JiangShengteng He

Abstract

Head and neck squamous cell carcinoma (HNSCC) is an invasive malignancy with high worldwide mortality. Growing evidence has indicated a pivotal correlation between HNSCC prognosis and immune signature. This study investigated an immune-related gene pairs (IRGPs) signature to predict the prognostic value of HNSCC patients. We constructed IRGPs via integrating multiple IRG expression data sets. Moreover, we established the predictive model base on the IRGPs for HNSCC, and utilized multidimensional bioinformatics methods to validate the robustness of prognostic value of the IRGPs signature. In addition, we explored the relationship between the IRGPs model and immune status. Seventeen IRGPs signature was built as the predictive model which predicted prognosis independently and reliably for HNSCC. Compared to the high-risk group, the low-risk group demonstrated a distinctly favorable prognosis including overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS). The low-risk group showed higher-immune score and lower-tumor purity than the high-risk group. In addition, the low-risk group exhibited higher expression of Programmed cell death 1 ligand 1 (PD-L1) and Microsatellite instability (MSI) score,...Continue Reading

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Datasets Mentioned

BETA
GSE41613

Methods Mentioned

BETA
RNA-seq

Software Mentioned

ESTIMATE
TIDE
R
glmnet R package
rms R
fgsea R package
GSEA
Immunology Database and Analysis Portal ( Immport )
CIBERSORT

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