PMID: 9532273Apr 9, 1998Paper

A silicone ventricular catheter coated with a combination of rifampin and trimethoprim for the prevention of catheter-related infections

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
W KohnenB Jansen

Abstract

So-called antiinfective catheters which are generated by incorporation of antimicrobial substances into polymers appear to be effectful devices in the prevention of catheter related infections. Such devices mainly act by prevention of bacterial colonization of the catheter surface rather than by inhibition of adherence. In a preceding study, we developed a rifampin-containing silicone catheter for the prevention of ventricular shunt infection. In the present study, this work was continued with a combination of antimicrobials incorporated in silicone ventricular catheters to reduce the risk of rifampin resistance and to expand the antimicrobial spectrum. We found that the drug release kinetics could be greatly influenced by the incorporation conditions. It was possible to incorporate an optimal antibiotic combination of rifampin and trimethoprim into the polymer resulting in defined release rates and a defined total release. A catheter loaded with this combination showed an excellent reduction of the colonization with Staphylococcus aureus (99.97% reduction within 3 hours) under in-vitro conditions.

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Citations

Oct 14, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Henry E AryanMichael L Levy
Feb 8, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Peter Kan, John Kestle
Mar 28, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Daniel M SciubbaGeorge I Jallo
Nov 6, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Scott L ParkerGeorge I Jallo
May 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bergthóra S SnorradóttirMár Másson
Mar 5, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bergthóra S SnorradóttirMár Másson
Apr 7, 2010·The Journal of Infection·Raquel Gutiérrez-González, Gregorio R Boto
Jun 14, 2003·The Journal of Pharmacy and Pharmacology·Roisin McCrorySean P Gorman
Sep 3, 2011·Journal of Neurosurgery. Pediatrics·Scott L ParkerMatthew J McGirt
Jun 4, 2008·Journal of Neurosurgery. Pediatrics·Regina EymannMichael Kiefer
Aug 5, 2003·The Laryngoscope·Frank SchmälKarsten Becker
Apr 16, 2002·Molecular Microbiology·Friedrich Götz
Jul 12, 2007·Journal of Biomaterials Science. Polymer Edition·Xuemei LiangK Y Simon Ng
Jan 31, 2008·Pediatric Neurosurgery·Daniel M SciubbaGeorge I Jallo
Dec 15, 2005·The International Journal of Artificial Organs·C von EiffB Jansen

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